Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

Jiaqing Hao; Rong Jin; Jun Zeng; Yuan Hua; Matthew S Yorek; Lianliang Liu; Anita Mandal; Junling Li; Huaiyu Zheng; Yanwen Sun; Yanmei Yi; Di Yin; Qi Zheng; Xiaohong Li; Chin K Ng; Eric C Rouchka; Nejat K Egilmez; Ali Jabbari; Bing Li

doi:10.1016/j.celrep.2022.111804

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Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

Journal article

Open access

Peer reviewed

Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

Jiaqing Hao, Rong Jin, Jun Zeng, Yuan Hua, Matthew S Yorek, Lianliang Liu, Anita Mandal, Junling Li, Huaiyu Zheng, Yanwen Sun, …

Cell reports (Cambridge), Vol.41(11), pp.111804-111804

12/13/2022

DOI: 10.1016/j.celrep.2022.111804

PMCID: PMC10193786

PMID: 36516778

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Abstract

Fats are essential in healthy diets, but how dietary fats affect immune cell function and overall health is not well understood. Mimicking human high-fat diets (HFDs), which are rich in different fatty acid (FA) components, we fed mice various HFDs from different fat sources, including fish oil and cocoa butter. Mice consuming the fish oil HFD exhibit a hair-loss phenotype. Further studies show that omega-3 (n-3) FAs in fish oil promote atypical infiltration of CD207 (langerin ) myeloid macrophages in skin dermis, which induce hair loss through elevated TNF-α signaling. Mechanistically, epidermal fatty acid binding protein (E-FABP) is demonstrated to play an essential role in inducing TNF-α-mediated hair loss by activating the n-3 FA/ROS/IL-36 signaling pathway in dermal resident macrophages. Absence of E-FABP abrogates fish oil HFD-induced murine hair loss. Altogether, these findings support a role for E-FABP as a lipid sensor mediating n-3 FA-regulated macrophage function and skin health.

Alopecia - metabolism

Animals

Diet, High-Fat - adverse effects

Dietary Fats - pharmacology

Fatty Acid-Binding Proteins - genetics

Fatty Acid-Binding Proteins - metabolism

Fatty Acids, Omega-3 - metabolism

Fish Oils - metabolism

Fish Oils - pharmacology

Humans

Macrophages - metabolism

Mice

Tumor Necrosis Factor-alpha - metabolism

Details

Title: Subtitle: Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
Creators: Jiaqing Hao
Rong Jin
Jun Zeng
Yuan Hua
Matthew S Yorek - University of Iowa
Lianliang Liu
Anita Mandal - University of Louisville
Junling Li - University of Louisville
Huaiyu Zheng - University of Louisville
Yanwen Sun
Yanmei Yi
Di Yin
Qi Zheng - University of Louisville
Xiaohong Li - University of Louisville
Chin K Ng - University of Louisville
Eric C Rouchka
Nejat K Egilmez - University of Louisville
Ali Jabbari
Bing Li
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.41(11), pp.111804-111804
DOI: 10.1016/j.celrep.2022.111804
PMID: 36516778
PMCID: PMC10193786
NLM abbreviation: Cell Rep
eISSN: 2211-1247
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: P20GM103436, P20GM135004, P30GM106396, R01AI137324, R01CA180986, U01CA272424; DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 12/13/2022
Academic Unit: Dermatology; Pathology
Record Identifier: 9984333159502771

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