Journal article
Contemporary Population-Based Comparison of Localized Ductal Adenocarcinoma and High-Risk Acinar Adenocarcinoma of the Prostate
Urology (Ridgewood, N.J.), Vol.86(4), pp.777-782
10/2015
DOI: 10.1016/j.urology.2015.07.009
PMID: 26196240
Abstract
To compare pathological characteristics, treatment patterns, and survival in patients with ductal adenocarcinoma (DC) compared to those with acinar adenocarcinoma (AC).
Using the National Cancer Database, we identified patients diagnosed with clinically localized (cN0, cM0) pure DC (n = 1328) and AC (n = 751,635) between 1998 and 2011. High-risk AC was defined as Gleason 8-10. Demographic, treatment, pathological, and survival characteristics of patients were compared.
Compared to patients with Gleason 8-10 AC, those with DC presented with lower mean prostate-specific antigen (10.3 vs 16.2 ng/mL, P <.001), had similar rates (11.7% vs 11.5%, P = .8) of clinical extra-capsular extension (stage ≥ cT3), and were more likely to undergo prostatectomy (54% vs 36%, P <.001). Compared to patients with Gleason 8-10 AC undergoing prostatectomy, those with DC had more favorable pathology: stage ≥ T3 (39% vs 52%, P <.001), fewer positive lymph nodes (4% vs 11%, P <.001), and fewer positive margins (25% vs 33%, P <.001). On Kaplan-Meier analysis, patients with DC had similar 5-year survival (75.0%, 95% confidence interval [CI] [71.7-78.9]) compared to those with Gleason 8-10 AC (77.1%, 95% CI [76.6%-77.6%], P = .2). On Cox multivariable analysis, patients with Gleason 8-10 AC had a similar risk of death compared to those with DC (hazards ratio = 0.92, 95% CI [0.69-1.23], P = 6).
In this large contemporary population-based series, patients with DC of the prostate presented with lower prostate-specific antigen, had more favorable pathological features, and similar overall survival compared to men with Gleason 8-10 AC.
Details
- Title: Subtitle
- Contemporary Population-Based Comparison of Localized Ductal Adenocarcinoma and High-Risk Acinar Adenocarcinoma of the Prostate
- Creators
- Vignesh T Packiam - University of ChicagoSanjay G Patel - University of ChicagoJoseph J Pariser - University of ChicagoKyle A Richards - University of Wisconsin–MadisonAdam B Weiner - University of ChicagoGladell P Paner - University of ChicagoDavid J VanderWeele - University of ChicagoGregory P Zagaja - University of ChicagoScott E Eggener - University of Chicago
- Resource Type
- Journal article
- Publication Details
- Urology (Ridgewood, N.J.), Vol.86(4), pp.777-782
- DOI
- 10.1016/j.urology.2015.07.009
- PMID
- 26196240
- ISSN
- 0090-4295
- eISSN
- 1527-9995
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Urology
- Record Identifier
- 9984320060802771
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