Contemporary Role of the Decipher® Test in Prostate Cancer Management: Current Practice and Future Perspectives

Deepansh Dalela; Björn Löppenberg; Akshay Sood; Jesse Sammon; Firas Abdollah

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Contemporary Role of the Decipher® Test in Prostate Cancer Management: Current Practice and Future Perspectives

Journal article

Open access

Contemporary Role of the Decipher® Test in Prostate Cancer Management: Current Practice and Future Perspectives

Deepansh Dalela, Björn Löppenberg, Akshay Sood, Jesse Sammon and Firas Abdollah

Reviews in urology, Vol.18(1), pp.1-9

2016

PMCID: PMC4859922

PMID: 27162506

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https://pmc.ncbi.nlm.nih.gov/articles/PMC4859922/View

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Abstract

We performed a systematic literature search to identify original articles and editorials about the Decipher(®) Prostate Cancer Test (GenomeDx Biosciences, San Diego, CA) to provide an overview of the current literature and its present role in urologic clinical practice. The Decipher test, which uses the expression of 22 selected RNA markers (from a total of over 1.4 million), showed a very high discrimination in predicting clinical metastasis (0.75-0.83) and cancer-specific mortality (0.78) in external validation studies, outperforming all routinely available clinicopathologic characteristics. Further, the timing of postoperative radiotherapy (adjuvant vs salvage) may be guided based on Decipher scores. The Decipher test was also the only independent predictor of clinical metastasis in patients with biochemical recurrence after surgery. The Decipher Genomic Resource Information Database (GRID) is a novel research tool that captures 1.4 million marker expressions per patient and may facilitate precision-guided, individualized care to patients with prostate cancer. In this era of precision medicine, Decipher, along with the Decipher GRID platform, is a promising genomic tool that may aid in managing prostate cancer patients throughout the continuum of care and delivering appropriate treatment at an individualized level.

Prostate Cancer

Genomic classifier

Treatment outcome

Neoplasm recurrence

Local/surgery

Decipher® Prostate Cancer Test

Details

Title: Subtitle: Contemporary Role of the Decipher® Test in Prostate Cancer Management: Current Practice and Future Perspectives
Creators: Deepansh Dalela - Henry Ford Health System
Björn Löppenberg - Henry Ford Health System
Akshay Sood - Henry Ford Health System
Jesse Sammon - Henry Ford Health System
Firas Abdollah - Henry Ford Health System
Resource Type: Journal article
Publication Details: Reviews in urology, Vol.18(1), pp.1-9
PMID: 27162506
PMCID: PMC4859922
NLM abbreviation: Rev Urol
ISSN: 1523-6161
Language: English
Date published: 2016
Academic Unit: Urology
Record Identifier: 9984958309402771

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