Journal article
Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study
The journal of clinical endocrinology and metabolism, Vol.104(10), pp.4356-4364
10/01/2019
DOI: 10.1210/jc.2018-02763
PMCID: PMC7296129
PMID: 31127824
Abstract
Abstract
Context
Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. Although data on glycemic profiles of healthy, nondiabetic individuals exist for older sensors, assessment of glycemic metrics with new-generation CGM devices is lacking.
Objective
To establish reference sensor glucose ranges in healthy, nondiabetic individuals across different age groups using a current generation CGM sensor.
Design
Multicenter, prospective study.
Setting
Twelve centers within the T1D Exchange Clinic Network.
Patients or Participants
Nonpregnant, healthy, nondiabetic children and adults (age ≥6 years) with nonobese body mass index.
Intervention
Each participant wore a blinded Dexcom G6 CGM, with once-daily calibration, for up to 10 days.
Main Outcome Measures
CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability.
Results
A total of 153 participants (age 7 to 80 years) were included in the analyses. Mean average glucose was 98 to 99 mg/dL (5.4 to 5.5 mmol/L) for all age groups except those over 60 years, in whom mean average glucose was 104 mg/dL (5.8 mmol/L). The median time between 70 to 140 mg/dL (3.9 to 7.8 mmol/L) was 96% (interquartile range, 93 to 98). Mean within-individual coefficient of variation was 17 ± 3%. Median time spent with glucose levels >140 mg/dL was 2.1% (30 min/d), and median time spent with glucose levels <70 mg/dL (3.9 mmol/L) was 1.1% (15 min/d).
Conclusion
By assessing across age groups in a healthy, nondiabetic population, normative sensor glucose data have been derived and will be useful as a benchmark for future research studies.
This study provides normative sensor glucose data in a healthy, nondiabetic population of children and adults.
Details
- Title: Subtitle
- Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study
- Creators
- Viral N Shah - Barbara Davis Center for Diabetes, Aurora, Colorado.Stephanie N DuBose - Jaeb Center for Health ResearchZoey Li - Jaeb Center for Health ResearchRoy W Beck - Jaeb Center for Health ResearchAnne L Peters - University of Southern CaliforniaRuth S Weinstock - SUNY Upstate Medical UniversityDavida Kruger - Henry Ford HospitalMichael Tansey - University of IowaDavid Sparling - University of Oklahoma Health Sciences CenterStephanie Woerner - Indiana UniversityFrancesco Vendrame - University of MiamiRichard Bergenstal - Park Nicollet ClinicWilliam V Tamborlane - Yale UniversitySara E Watson - University of LouisvilleJennifer Sherr - Yale University
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.104(10), pp.4356-4364
- Publisher
- Endocrine Society
- DOI
- 10.1210/jc.2018-02763
- PMID
- 31127824
- PMCID
- PMC7296129
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Grant note
- Leona M. and Harry B. Helmsley Charitable Trust (10.13039/100007028)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984353933202771
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