Journal article
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure
Hypertension (Dallas, Tex. 1979), Vol.80(3), pp.650-658
03/01/2023
DOI: 10.1161/HYPERTENSIONAHA.122.20081
PMCID: PMC10128890
PMID: 36601916
Abstract
Supine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous positive airway pressure (CPAP) had a Valsalva-like blood-pressure-lowering effect that could be used to treat nocturnal supine hypertension in these patients, while reducing nocturnal pressure diuresis and improving daytime OH.
In Protocol 1, we determined the acute hemodynamic effects of increasing levels of CPAP (0, 4, 8, 12, and 16 cm H
O, 3 minutes each) in 26 patients with autonomic failure and supine hypertension studied while awake and supine. In Protocol 2 (n=11), we compared the effects of overnight therapy with CPAP (8-12 cm H
O for 8 hours) versus placebo on nocturnal supine hypertension, nocturnal diuresis and daytime OH in a 2-night crossover study.
In Protocol 1, acute CPAP (4-16 cm H
O) decreased systolic blood pressure in a dose-dependent manner (maximal drop 22±4 mmHg with CPAP 16) due to reductions in stroke volume (-16+3%) and cardiac output (-14±3%). Systemic vascular resistance and heart rate remained unchanged. In Protocol 2, overnight CPAP lowered nighttime systolic blood pressure (maximal change -23±5 versus placebo -1±7 mmHg;
=0.023) and was associated with lower nighttime diuresis (609±84 versus placebo 1004±160 mL;
=0.004) and improved morning orthostatic tolerance (AUC
642±121 versus placebo 410±109 mmHg*min;
=0.014).
CPAP is a novel nonpharmacologic approach to treat the supine hypertension of autonomic failure while improving nocturia and daytime OH.
URL: https://www.
gov; Unique identifier: NCT03312556.
Details
- Title: Subtitle
- Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure
- Creators
- Luis E Okamoto - Vanderbilt University Medical CenterJorge E Celedonio - Vanderbilt University Medical CenterEmily C Smith - Vanderbilt University Medical CenterSachin Y Paranjape - Vanderbilt University Medical CenterBonnie K Black - Vanderbilt University Medical CenterAmr Wahba - Vanderbilt University Medical CenterJin-Woo Park - Vanderbilt University Medical CenterCyndya A Shibao - Vanderbilt University Medical CenterAndré Diedrich - Vanderbilt University Medical CenterItalo Biaggioni - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.80(3), pp.650-658
- DOI
- 10.1161/HYPERTENSIONAHA.122.20081
- PMID
- 36601916
- PMCID
- PMC10128890
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- R01 HL122847 / NHLBI NIH HHS R01 HL142583 / NHLBI NIH HHS R01 HL161095 / NHLBI NIH HHS U54 NS065736 / NINDS NIH HHS P01 HL056693 / NHLBI NIH HHS R01 HL144568 / NHLBI NIH HHS UL1 TR000445 / NCATS NIH HHS
- Language
- English
- Date published
- 03/01/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702937402771
Metrics
3 Record Views