Journal article
Continuous measurement of cerebral blood flow in anesthetized cats and dogs
The American journal of physiology, Vol.241(2), pp.H228-234
08/1981
DOI: 10.1152/ajpheart.1981.241.2.H228
PMID: 7270711
Abstract
We have developed a method for virtually continuous measurement of changes in cerebral blood flow (CBF) in cats and dogs. CBF was computed by multiplying cross-sectional area (CSA) and mean blood velocity in a pial artery. CSA was determined by measuring pial artery diameter with an electronic micrometer every 2-4 s through a cranial window. Velocity was measured continuously with a pulsed Doppler crystal positioned under a pial artery. CBF was determined in 12 anesthetized cats during 1) control, 2) hypocapnia, 3) hypercapnia, and 4) hypercapnia plus hypertension. Microspheres were injected under steady-state conditions to compare the two methods. During control, the diameter of the cerebral arteries observed was 388 +/- 28 (SE) micrometers, and CBF measured with microspheres was 40 +/- 4 ml.min-1.100 g-1. CBF decreased 18 +/- 2% during hypocapnia and increased 152 +/- 36% during hypercapnia. During steady-state conditions, the correlation coefficient between changes in CBF (CSA X velocity and microspheres) was 0.94, and the slope of the regression line was 1.02. In similar studies on seven anesthetized dogs, the correlation coefficient between CSA X velocity and microspheres was 0.98, and the slope of the regression line was 0.94. We conclude that the product of CSA and blood velocity of a pial artery provides accurate on-line measurement of changes in CBF.
Details
- Title: Subtitle
- Continuous measurement of cerebral blood flow in anesthetized cats and dogs
- Creators
- David W BusijaDonald D HeistadMelvin L Marcus
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.241(2), pp.H228-234
- DOI
- 10.1152/ajpheart.1981.241.2.H228
- PMID
- 7270711
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- United States
- Grant note
- HL-16066 / NHLBI NIH HHS HL-00328 / NHLBI NIH HHS HL-06016 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/1981
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040494302771
Metrics
19 Record Views