Journal article
Continuous oral capecitabine at fixed dose in patients older than 75 years with metastatic colorectal and gastric cancer: A study of the Multidisciplinary Oncology Group on Gastrointestinal Tumors
Anti-cancer drugs, Vol.19(1), pp.91-96
01/2008
DOI: 10.1097/CAD.0b013e3282f21363
PMID: 18043134
Abstract
The aim of this study was to investigate the safety profile of continuous oral capecitabine at fixed dose in patients older than 75 years, having metastatic colorectal and gastric cancer. Capecitabine was administered at a fixed dose of 2000 mg daily without interruptions. Thirty-four patients were considered evaluable for toxicity and efficacy. The median age was 81 years (range 76–85). The median duration of treatment was 113 days (range 24–238 days). No grade 4 toxicity was observed. One patient had grade 3 nausea and vomiting, and one had grade 3 diarrhea. Partial responses were observed in six patients with colorectal cancer, and in one patient with gastric cancer. This study suggests that continuous oral capecitabine at a fixed daily dose of 2000 mg is well tolerated, and that it allows for the simplification and ease of dosing in elderly patients with metastatic colorectal and gastric cancer.
Details
- Title: Subtitle
- Continuous oral capecitabine at fixed dose in patients older than 75 years with metastatic colorectal and gastric cancer: A study of the Multidisciplinary Oncology Group on Gastrointestinal Tumors
- Creators
- Roberto Petrioli - University of SienaAlessandra Pascucci - University of SienaEdoardo Francini - University of SienaStefania Marsili - University of SienaAnna Ida Fiaschi - University of SienaSerenella Civitelli - University of SienaGabriello Tanzini - University of SienaSandra Battistelli - University of SienaMarco Lorenzi - University of SienaFranco Roviello - University of SienaGuido Francini - University of SienaMultidisciplinary Oncology Group on Gastrointestinal Tumors
- Resource Type
- Journal article
- Publication Details
- Anti-cancer drugs, Vol.19(1), pp.91-96
- DOI
- 10.1097/CAD.0b013e3282f21363
- PMID
- 18043134
- ISSN
- 0959-4973
- eISSN
- 1473-5741
- Number of pages
- 6
- Language
- English
- Date published
- 01/2008
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221141602771
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