Continuum Finite Element Analysis Generalizes In Vivo Trabecular Bone Microstructural Strength Measures between Two CT Scanners with Different Image Resolution

Indranil Guha; Xiaoliu Zhang; Syed Ahmed Nadeem; Steven M Levy; Punam Kumar Saha

doi:10.1088/2057-1976/acbb0a

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Continuum Finite Element Analysis Generalizes In Vivo Trabecular Bone Microstructural Strength Measures between Two CT Scanners with Different Image Resolution

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Continuum Finite Element Analysis Generalizes In Vivo Trabecular Bone Microstructural Strength Measures between Two CT Scanners with Different Image Resolution

Indranil Guha, Xiaoliu Zhang, Syed Ahmed Nadeem, Steven M Levy and Punam Kumar Saha

Biomedical physics & engineering express, Vol.9(2), 025012

03/2023

DOI: 10.1088/2057-1976/acbb0a

PMCID: PMC9945196

PMID: 36763987

Appears in UI Libraries Support Open Access

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Abstract

Fragility of trabecular bone (Tb) microstructure is increased in osteoporosis, which is associated with rapid bone loss and enhanced fracture-risk. Accurate assessment of Tb strength using in vivo imaging available in clinical settings will be significant for management of osteoporosis and understanding its pathogenesis. Emerging CT technology, featured with high image resolution, fast scan-speed, and wide clinical access, is a promising alternative for in vivo Tb imaging. However, variation in image resolution among different CT scanners pose a major hurdle in CT-based bone studies. This paper presents nonlinear continuum finite element (FE) methods for computation of Tb strength from in vivo CT imaging and evaluates their generalizability between two scanners with different image resolution. Continuum FE-based measures of Tb strength under different loading conditions were found to be highly reproducible (ICC ≥ 0.93) using ankle images of twenty healthy volunteers acquired on low- and high-resolution CT scanners 44.6±2.7 days apart. FE stress propagation was mostly confined to Tb micro-network (2.3±1.9 MPa) with nominal leakages over the marrow space (0.4±0.5 MPa) complying with the fundamental principle of mechanics at in vivo imaging. In summary, nonlinear continuum FE-based Tb strength measures are reproducible among different CT scanners and suitable for multi-site longitudinal human studies.

Osteoporosis

micro-structure

Multiscanner Generalizability

Nonlinear FE Modelling

Bone Strength

trabecular bone

UIOWA OA Agreement

Details

Title: Subtitle: Continuum Finite Element Analysis Generalizes In Vivo Trabecular Bone Microstructural Strength Measures between Two CT Scanners with Different Image Resolution
Creators: Indranil Guha - University of Iowa
Xiaoliu Zhang - University of Iowa
Syed Ahmed Nadeem - Department of Radiology, University of Iowa, 220 Hawkins Drive, General Hospital, Iowa City, Iowa, 52246, UNITED STATES
Steven M Levy - Department of Epidemiology , University of Iowa, N329 Dental Science Building, Iowa City, Iowa, 52242, UNITED STATES
Punam Kumar Saha - University of Iowa
Resource Type: Journal article
Publication Details: Biomedical physics & engineering express, Vol.9(2), 025012
DOI: 10.1088/2057-1976/acbb0a
PMID: 36763987
PMCID: PMC9945196
NLM abbreviation: Biomed Phys Eng Express
ISSN: 2057-1976
eISSN: 2057-1976
Publisher: IOP Publishing
Grant note: DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01 DE12101
Language: English
Electronic publication date: 02/10/2023
Date published: 03/2023
Academic Unit: Preventive and Community Dentistry; Radiology; Electrical and Computer Engineering; Epidemiology
Record Identifier: 9984366359902771

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