Contralateral flow reduction in unilateral stroke: evidence for transhemispheric diaschisis

H. L LAGREZE; R. L LEVINE; K. L PEDULA; R. J NICKLES; J. S SUNDERLAND; B. R ROWE

doi:10.1161/01.STR.18.5.882

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Contralateral flow reduction in unilateral stroke: evidence for transhemispheric diaschisis

Journal article

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Contralateral flow reduction in unilateral stroke: evidence for transhemispheric diaschisis

H. L LAGREZE, R. L LEVINE, K. L PEDULA, R. J NICKLES, J. S SUNDERLAND and B. R ROWE

Stroke (1970), Vol.18(5), pp.882-886

1987

DOI: 10.1161/01.STR.18.5.882

PMID: 3498240

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Abstract

Using clinical presentation, angiography, computed tomography, and nuclear magnetic resonance imaging, 7 patients were identified who had strictly unilateral hemispheric infarction and unilateral cerebrovascular disease. In 6, cerebral blood flow measured by fluorine-18-fluoromethane inhalation and positron emission tomography was reduced in the contralateral hemisphere (p less than 0.05). Multiple regression analysis demonstrated a high correlation between contralateral flow reduction and the degree of flow impairment in the infarcted area (r = 0.941, p = 0.0014) but not with age, risk factor profile, blood pressure, PCO2, hematocrit, or duration of stroke. We conclude that transhemispheric diaschisis best explains the contralateral flow reduction seen in supratentorial ischemic stroke.

Neurology

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Details

Title: Subtitle: Contralateral flow reduction in unilateral stroke: evidence for transhemispheric diaschisis
Creators: H. L LAGREZE - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
R. L LEVINE - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
K. L PEDULA - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
R. J NICKLES - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
J. S SUNDERLAND - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
B. R ROWE - William S. Middleton memorial veterans hosp., dep. neurology, Madison WI 53705, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.18(5), pp.882-886
DOI: 10.1161/01.STR.18.5.882
PMID: 3498240
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 1987
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984046828802771

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