Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy

Volker STRAUB; Kathleen M DONAHUE; Valérie ALLAMAND; Robin L DAVISSON; Young R KIM; Kevin P CAMPBELL

doi:10.1002/1522-2594(200010)44:4<655::AID-MRM22>3.0.CO;2-T

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Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy

Journal article

Open access

Peer reviewed

Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy

Volker STRAUB, Kathleen M DONAHUE, Valérie ALLAMAND, Robin L DAVISSON, Young R KIM and Kevin P CAMPBELL

Magnetic resonance in medicine, Vol.44(4), pp.655-659

2000

DOI: 10.1002/1522-2594(200010)44:4<655::AID-MRM22>3.0.CO;2-T

PMID: 11025524

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https://doi.org/10.1002/1522-2594(200010)44:4<655::AID-MRM22>3.0.CO;2-TView

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Abstract

Membrane lesions play an early role in the pathogenesis of muscular dystrophy. Using a new albumin-targeted contrast agent (MS-325), sarcolemmal integrity of two animal models for muscular dystrophy was studied by MRI. Intravenously injected MS-325 does not enter skeletal muscle of normal mice. However, mdx and Sgca-null mutant mice, animal models for Duchenne and sarcoglycan-deficient limb-girdle muscular dystrophy, respectively, showed significant accumulation of MS-325 in skeletal muscle. The results suggest that contrast agent-enhanced MRI could serve as a common, noninvasive imaging procedure for evaluating the localization, extent, and mechanisms of skeletal muscle damage in muscular dystrophy. Furthermore, this method is expected to facilitate assessment of therapeutic approaches in these diseases.

Neurology

Radiodiagnosis. Nmr imagery. Nmr spectrometry

Osteoarticular system. Muscles

Investigative techniques, diagnostic techniques (general aspects)

Biological and medical sciences

Medical sciences

Diseases of striated muscles. Neuromuscular diseases

Details

Title: Subtitle: Contrast agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy
Creators: Volker STRAUB - Howard Hughes Medical Institute, Department of Physiology and Biophysics and Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, United States
Kathleen M DONAHUE - Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Valérie ALLAMAND - Howard Hughes Medical Institute, Department of Physiology and Biophysics and Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, United States
Robin L DAVISSON - Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa, United States
Young R KIM - Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Kevin P CAMPBELL - Howard Hughes Medical Institute, Department of Physiology and Biophysics and Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine, Vol.44(4), pp.655-659
Publisher: Williams & Wilkins; Baltimore, MD
DOI: 10.1002/1522-2594(200010)44:4<655::AID-MRM22>3.0.CO;2-T
PMID: 11025524
ISSN: 0740-3194
eISSN: 1522-2594
Language: English
Date published: 2000
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984068274002771

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