Journal article
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
Journal of hypertension, Vol.17(12 Suppl), pp.1949-1953
12/1999
DOI: 10.1097/00004872-199917121-00026
PMID: 10703894
Abstract
OBJECTIVERecent advances in understanding the neuroendocrine pathways regulating appetite, metabolism and body weight afford an opportunity to explore further the mechanisms by which obesity influences arterial pressure. ob/ob(Lep/Lep) mice have a mutation in the ob gene and are leptin-deficient. Leptin possesses pressor actions and has been shown to increase arterial pressure when infused chronically or over-expressed transgenically. In contrast, agouti yellow obese(A) mice have over-expression of an agouti peptide that blocks melanocortin receptors. Stimulation of melanocortin receptors by α-melanocyte-stimulating hormone decreases arterial pressure.
DESIGN AND METHODSThis study measured arterial pressure in leptin-deficient ob/ob mice, agouti yellow obese mice and their lean controls to test the hypothesis that the effects of obesity on arterial pressure are importantly infuenced by the genetic and neuroendocrine mechanisms causing the obesity. We measured arterial pressure directly in conscious ob/ob mice (n = 14), agouti yellow obese mice (n = 6) and the same number of lean littermates.
RESULTSBody weight was nearly twice as high in ob/ob mice as in their lean controls, but mean arterial pressure was significantly lower in ob/ob mice (92 ± 3 mmHg) compared with their lean controls (106 ± 2 mmHg; P = 0.00017). In contrast, mean arterial pressure was significantly higher in agouti yellow obese mice (124 ± 3 mmHg) than in their lean controls (99 ± 1 mmHg; P = 0.000002) despite the fact that the agouti mice had milder obesity.
CONCLUSIONSThis study prompts three conclusions(1) leptin-deficient ob/ob mice and agouti yellow obese mice have contrasting blood pressure responses to obesity, (2) obesity does not invariably increase arterial pressure in mice, and (3) the arterial pressure response to obesity may depend critically on the underlying genetic and neuroendocrine mechanisms.
Details
- Title: Subtitle
- Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
- Creators
- Allyn Mark - 1Specialized Center of Research in Hypertension Genetics and the Cardiovascular Center, Iowa City, Iowa, USA 2Department of Internal Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, Iowa, USA 3Department of Physiology and Biophysics, University of Iowa, and Veterans Administration Medical Center, Iowa City, Iowa, USARichard ShafferMarcelo CorreiaDonald MorganCurt SigmundWilliam Haynes
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension, Vol.17(12 Suppl), pp.1949-1953
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00004872-199917121-00026
- PMID
- 10703894
- ISSN
- 0263-6352
- eISSN
- 1473-5598
- Language
- English
- Date published
- 12/1999
- Academic Unit
- Molecular Physiology and Biophysics; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094501402771
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