Journal article
Contribution of alternative splicing to breast cancer metastasis
Journal of cancer metastasis and treatment, Vol.2019(3), pp.73-79
03/22/2019
DOI: 10.20517/2394-4722.2018.96
PMCID: PMC6857724
PMID: 31737791
Abstract
Alternative splicing is a major contributor to transcriptome and proteome diversity in eukaryotes. Comparing to normal samples, about 30% more alternative splicing events were recently identified in 32 cancer types included in The Cancer Genome Atlas database. Some alternative splicing isoforms and their encoded proteins contribute to specific cancer hallmarks. In this review, we will discuss recent progress regarding the contributions of alternative splicing to breast cancer metastasis. We plan to dissect the role of MTDH, CD44 and their interaction with other mRNA splicing factors. We believe an in-depth understanding of the mechanism underlying the contribution of splicing to breast cancer metastasis will provide novel strategies to the management of breast cancer.
Keywords: Breast cancer; CD44; MTDH; epithelial-mesenchymal transition; metastasis; splicing.
Details
- Title: Subtitle
- Contribution of alternative splicing to breast cancer metastasis
- Creators
- Xiangbing Meng - Roy J. and Lucille A. Carver College of MedicineShujie Yang - Roy J. and Lucille A. Carver College of MedicineJun Zhang - Roy J. and Lucille A. Carver College of MedicineHuimin Yu - Shenzhen University
- Resource Type
- Journal article
- Publication Details
- Journal of cancer metastasis and treatment, Vol.2019(3), pp.73-79
- DOI
- 10.20517/2394-4722.2018.96
- PMID
- 31737791
- PMCID
- PMC6857724
- NLM abbreviation
- J Cancer Metastasis Treat
- ISSN
- 2394-4722
- eISSN
- 2454-2857
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: RO1CA184101
- Language
- English
- Date published
- 03/22/2019
- Academic Unit
- Pathology; Internal Medicine
- Record Identifier
- 9984201113902771
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