Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States

Elizabeth L Yanik; Meredith S Shiels; Jodi M Smith; Christina A Clarke; Charles F Lynch; Amy R Kahn; Lori Koch; Karen S Pawlish; Eric A Engels

doi:10.1002/cncr.30923

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Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States

Journal article

Open access

Peer reviewed

Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States

Elizabeth L Yanik, Meredith S Shiels, Jodi M Smith, Christina A Clarke, Charles F Lynch, Amy R Kahn, Lori Koch, Karen S Pawlish and Eric A Engels

Cancer, Vol.123(23), pp.4663-4671

12/01/2017

DOI: 10.1002/cncr.30923

PMCID: PMC5693631

PMID: 28759103

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Abstract

Pediatric solid organ transplant recipients have a 100 to 200 times higher risk of non-Hodgkin lymphoma (NHL) than the general pediatric population. Consequently, transplant-related NHL may contribute considerably to the pediatric NHL burden in the United States. A cohort study using a linkage between the US transplant registry and 16 cancer registries was conducted. Cancer incidence rates were calculated for people less than 20 years old in the transplant and general populations. Rates were applied to transplant registry and US census data to estimate pediatric NHL counts for transplant recipients and the general population. During 1990-2012, an estimated 22,270 NHLs were diagnosed in US children and adolescents; they included 628 cases diagnosed in transplant recipients. Thus, 2.82% of pediatric NHL diagnoses in the general population (95% confidence interval [CI], 2.45%-3.19%) occurred in transplant recipients. Among transplant recipients, the most common subtypes were diffuse large B-cell lymphoma (DLBCL; 64.5% of cases) and Burkitt lymphoma (BL; 8.6%). For DLBCL and BL, transplant recipients contributed 7.62% (95% CI, 6.35%-8.88%) and 0.87% (95% CI, 0.51%-1.23%) of diagnoses, respectively. The proportion of NHLs that occurred in transplant recipients was highest among children less than 5 years old (4.46%; 95% CI, 3.24%-5.69%) and in more recent calendar years (3.73% in 2010-2012; 95% CI, 2.07%-5.39%). DLBCL patterns were similar, with transplant recipients contributing 19.78% of cases among children less than 5 years old (95% CI, 12.89%-26.66%) and 11.4% of cases in 2010-2012 (95% CI, 5.54%-17.28%). Among children and adolescents, solid organ transplant recipients contribute a substantial fraction of NHL diagnoses, particularly DLBCL diagnoses. This fraction has increased over time. Prevention efforts targeted toward this group could reduce the overall pediatric NHL burden. Cancer 2017;123:4663-4671. © 2017 American Cancer Society.

United States - epidemiology

Prognosis

Follow-Up Studies

Humans

Child, Preschool

Infant

Male

Lymphoma, Large B-Cell, Diffuse - etiology

Transplant Recipients

Incidence

Young Adult

Lymphoma, Large B-Cell, Diffuse - epidemiology

Organ Transplantation - adverse effects

Adolescent

Adult

Female

Neoplasm Staging

Child

Infant, Newborn

Cohort Studies

Details

Title: Subtitle: Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States
Creators: Elizabeth L Yanik - Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri
Meredith S Shiels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Jodi M Smith - Seattle Children's Hospital
Christina A Clarke - GRAIL, Inc, Menlo Park, California
Charles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, Iowa
Amy R Kahn - New York State Cancer Registry, New York, New York
Lori Koch - Illinois State Cancer Registry, Springfield, Illinois
Karen S Pawlish - Cancer Epidemiology Services, New Jersey Department of Health, Trenton, New Jersey
Eric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Resource Type: Journal article
Publication Details: Cancer, Vol.123(23), pp.4663-4671
Publisher: United States
DOI: 10.1002/cncr.30923
PMID: 28759103
PMCID: PMC5693631
ISSN: 0008-543X
eISSN: 1097-0142
Grant note: N01PC35142 / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS Z01 CP010150-09 / Intramural NIH HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS N01CP45503 / NCI NIH HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS Z01 CP010150-08 / Intramural NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS Z01 CP010176-07 / Intramural NIH HHS HHSN261201000032C / NCI NIH HHS N01PC35143 / NCI NIH HHS Z99 CA999999 / Intramural NIH HHS HHSN261201300019C / NCI NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
Language: English
Date published: 12/01/2017
Academic Unit: Epidemiology
Record Identifier: 9983995056602771

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