Contribution of venous resistance to total vascular resistance in skeletal muscle

Wadie A Abdel-Sayed; Francois M Abboud; Dennis R Ballard

doi:10.1152/ajplegacy.1970.218.5.1291

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Contribution of venous resistance to total vascular resistance in skeletal muscle

Journal article

Peer reviewed

Contribution of venous resistance to total vascular resistance in skeletal muscle

Wadie A Abdel-Sayed, Francois M Abboud and Dennis R Ballard

The American journal of physiology, Vol.218(5), pp.1291-1295

05/1970

DOI: 10.1152/ajplegacy.1970.218.5.1291

PMID: 4314567

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Abstract

Experiments were done on dogs to study the responsiveness of small veins in an isolated skeletal muscle preparation (gracilis) and to determine the contribution of venous resistance to the increase in total vascular resistance in this bed during various vasoconstrictor stimuli. Venous responses in the cutaneous hindpaw were compared with those in the muscle. The gracilis and hindpaw were perfused separately and simultaneously with blood. .At constant rates of flow changes in perfusion pressure reflected changes in total resistance and changes in small vein pressure reflected changes in venous resistance. The distal ends of the cut sciatic and obturator nerves were stimulated after neuromuscular blockade. Graded doses of various vasoconstrictor agents were infused intra-arterially. The results indicate that, in the muscle, venoconstrictor responses to all the vasoconstrictor stimuli used are either nil or small and contribute minimally to the increases in total resistance. In contrast, venous responses observed simultaneously’in the paw are much greater during nerve stimulation and during infusions of norepinephrine, dopamine, serotonin, and angiotensin. Only vasopressin caused a greater venous constriction in the muscle.

Norepinephrine - pharmacology

Angiotensin II - pharmacology

Hindlimb

Vascular Resistance

Electric Stimulation

Obturator Nerve

Dopamine - pharmacology

Vasopressins - pharmacology

Male

Serotonin - pharmacology

Animals

Veins

Perfusion

Vasomotor System - physiology

Dogs

Blood Pressure - drug effects

Sciatic Nerve

Muscles - blood supply

Details

Title: Subtitle: Contribution of venous resistance to total vascular resistance in skeletal muscle
Creators: Wadie A Abdel-Sayed
Francois M Abboud
Dennis R Ballard
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.218(5), pp.1291-1295
DOI: 10.1152/ajplegacy.1970.218.5.1291
PMID: 4314567
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: American Physiological Society; United States
Language: English
Date published: 05/1970
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984025440702771

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