Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects

Matthew R Hodges; George B Richerson

doi:10.1016/j.resp.2008.05.014

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Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects

Journal article

Peer reviewed

Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects

Matthew R Hodges and George B Richerson

Respiratory physiology & neurobiology, Vol.164(1-2), pp.222-232

12/10/2008

DOI: 10.1016/j.resp.2008.05.014

PMCID: PMC2642893

PMID: 18595785

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https://www.ncbi.nlm.nih.gov/pmc/articles/2642893View

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Abstract

Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter produced by a small number of neurons in the midbrain, pons and medulla. These neurons project widely throughout the neuraxis, where they release 5-HT and co-localized neuropeptides such as substance P (SP) and thyrotropin-releasing hormone (TRH). Each of these chemicals produce effects largely through G protein-coupled receptors, second messenger systems and subsequent neuromodulatory effects on target neurons. Emerging evidence suggests that 5-HT has additional modes of action during development and in adult mammals, including trophic effects (neurogenesis, cell differentiation, proliferation, migration and maturation) and influences on synaptic plasticity. Here, we discuss some of the neuromodulatory and trophic roles of 5-HT in general and in the context of respiratory control, as well as the regulation of release of modulatory neurotransmitters from 5-HT neurons. Future directions of study are also discussed.

Motor Neurons - physiology

Humans

Neurotransmitter Agents - metabolism

Nerve Growth Factors - metabolism

Serotonin - pharmacology

Brain Stem - cytology

Nerve Growth Factors - pharmacology

Animals

Respiratory System - metabolism

Neurotransmitter Agents - pharmacology

Respiration - drug effects

Serotonin - metabolism

Motor Neurons - drug effects

Details

Title: Subtitle: Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects
Creators: Matthew R Hodges - Department of Neurology and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA. Matthew.hodges@yale.edu
George B Richerson
Resource Type: Journal article
Publication Details: Respiratory physiology & neurobiology, Vol.164(1-2), pp.222-232
DOI: 10.1016/j.resp.2008.05.014
PMID: 18595785
PMCID: PMC2642893
NLM abbreviation: Respir Physiol Neurobiol
ISSN: 1569-9048
eISSN: 1878-1519
Publisher: Netherlands
Grant note: R01 HD052772-02 / NICHD NIH HHS R01 HD052772 / NICHD NIH HHS P01 HD036379-117765 / NICHD NIH HHS P01 HD036379 / NICHD NIH HHS
Language: English
Date published: 12/10/2008
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020635002771

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