Journal article
Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin
Current hypertension reports, Vol.20(3), pp.25-9
03/19/2018
DOI: 10.1007/s11906-018-0824-8
PMCID: PMC5882211
PMID: 29556733
Abstract
Here, we review the current understanding of the functional neuroanatomy of neurons expressing Agouti-related peptide (AgRP) and the angiotensin 1A receptor (AT
) within the arcuate nucleus (ARC) in the control of energy balance.
The development and maintenance of obesity involves suppression of resting metabolic rate (RMR). RMR control is integrated via AgRP and proopiomelanocortin neurons within the ARC. Their projections to other hypothalamic and extrahypothalamic nuclei contribute to RMR control, though relatively little is known about the contributions of individual projections and the neurotransmitters involved. Recent studies highlight a role for AT
, localized to AgRP neurons, but the specific function of AT
within these cells remains unclear. AT
functions within AgRP neurons to control RMR, but additional work is required to clarify its role within subpopulations of AgRP neurons projecting to distinct second-order nuclei, and the molecular mediators of its signaling within these cells.
Details
- Title: Subtitle
- Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin
- Creators
- Lisa L Morselli - Department of Internal Medicine, Division of Endocrinology, University of Iowa, Iowa City, IA, 52242, USAKristin E Claflin - Department of Pharmacology, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USAHuxing Cui - Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, 52242, USAJustin L Grobe - Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, 52242, USA. justin-grobe@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.20(3), pp.25-9
- DOI
- 10.1007/s11906-018-0824-8
- PMID
- 29556733
- PMCID
- PMC5882211
- NLM abbreviation
- Curr Hypertens Rep
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Publisher
- United States
- Grant note
- T32 HL007121 / NHLBI NIH HHS T32 HL007638 / NHLBI NIH HHS F32 DK117510 / NIDDK NIH HHS R21 MH109920 / NIMH NIH HHS P01 HL084207 / NHLBI NIH HHS R01 HL127673 / NHLBI NIH HHS R01 HL134850 / NHLBI NIH HHS
- Language
- English
- Date published
- 03/19/2018
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040394902771
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