Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Anh-Vu Do; Adil Akkouch; Brian Green; Ibrahim Ozbolat; Amer Debabneh; Sean Geary; Aliasger K Salem

doi:10.1007/s10439-016-1648-9

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Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Journal article

Open access

Peer reviewed

Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

Anh-Vu Do, Adil Akkouch, Brian Green, Ibrahim Ozbolat, Amer Debabneh, Sean Geary and Aliasger K Salem

Annals of biomedical engineering, Vol.45(1), pp.297-305

01/2017

DOI: 10.1007/s10439-016-1648-9

PMCID: PMC5124557

PMID: 27234816

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Abstract

Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.

Alginates - pharmacology

Fluorescent Dyes - chemistry

Fluorescent Dyes - pharmacokinetics

Lactic Acid - chemistry

Humans

Polyglycolic Acid - pharmacology

Delayed-Action Preparations - chemistry

Glucuronic Acid - pharmacokinetics

Hexuronic Acids - chemistry

Hexuronic Acids - pharmacokinetics

Lactic Acid - pharmacokinetics

Glucuronic Acid - pharmacology

Polyglycolic Acid - pharmacokinetics

Alginates - chemistry

Delayed-Action Preparations - pharmacology

Polyglycolic Acid - chemistry

Delayed-Action Preparations - pharmacokinetics

HEK293 Cells

Fluorescent Dyes - pharmacology

Glucuronic Acid - chemistry

Lactic Acid - pharmacology

Printing, Three-Dimensional

Alginates - pharmacokinetics

Hexuronic Acids - pharmacology

Details

Title: Subtitle: Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes
Creators: Anh-Vu Do - Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA
Adil Akkouch - Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA
Brian Green - Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA
Ibrahim Ozbolat - The Huck Institutes of the Life Sciences, Penn State University, State College, PA, USA
Amer Debabneh - Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA
Sean Geary - Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, USA
Aliasger K Salem - Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA. aliasger-salem@uiowa.edu
Resource Type: Journal article
Publication Details: Annals of biomedical engineering, Vol.45(1), pp.297-305
DOI: 10.1007/s10439-016-1648-9
PMID: 27234816
PMCID: PMC5124557
NLM abbreviation: Ann Biomed Eng
ISSN: 1573-9686
eISSN: 1573-9686
Publisher: Springer Science and Business Media LLC; United States
Grant note: P30 CA086862 / NCI NIH HHS R21 DE024206 / NIDCR NIH HHS
Language: English
Date published: 01/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9983985978102771

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