Journal article
Controlling the urge for a Ca2+ surge: all‐or‐none Ca2+ release in neurons
BioEssays, Vol.21(9), pp.743-750
09/1999
DOI: 10.1002/(SICI)1521-1878(199909)21:9<743::AID-BIES5>3.0.CO;2-M
PMID: 10462414
Abstract
Changes in the intracellular calcium concentration ([Ca2+]i) convey signals that are essential to the life and death of neurons. Ca2+‐induced Ca2+‐release (CICR), a process in which a modest elevation in [Ca2+]i is amplified by a secondary release of Ca2+ from stores within the cell, plays a prominent role in shaping neuronal [Ca2+]i signals. When CICR becomes regenerative, an explosive increase in [Ca2+]i generates a Ca2+ wave that spreads throughout the cell. A discrete threshold controls activation of this all‐or‐none behavior and cellular context adjusts the threshold. Thus, the store acts as a switch that determines whether a given pattern of electrical activity will produce a local or global Ca2+ signal. This gatekeeper function seems to control some forms of Ca2+‐triggered plasticity in neurons. BioEssays 21:743–750, 1999. © 1999 John Wiley & Sons, Inc.
Details
- Title: Subtitle
- Controlling the urge for a Ca2+ surge: all‐or‐none Ca2+ release in neurons
- Creators
- Yuriy M UsachevStanley A Thayer
- Resource Type
- Journal article
- Publication Details
- BioEssays, Vol.21(9), pp.743-750
- Publisher
- John Wiley & Sons, Inc; New York
- DOI
- 10.1002/(SICI)1521-1878(199909)21:9<743::AID-BIES5>3.0.CO;2-M
- PMID
- 10462414
- ISSN
- 0265-9247
- eISSN
- 1521-1878
- Number of pages
- 8
- Grant note
- The National Science Foundation (IBN9412654) National Institutes of Health (DA07304; DA09293)
- Language
- English
- Date published
- 09/1999
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984070522402771
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