Journal article
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
Circulation research, Vol.124(1), pp.161-169
01/04/2019
DOI: 10.1161/CIRCRESAHA.118.314216
PMCID: PMC6350935
PMID: 30605412
Abstract
On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present, and >40 scientists presented their latest work on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers, and physicians in the field of cardiovascular sciences met and discussed the most recent advances in their work and proposed future strategies for overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical, and mechanical cues to cells to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here, we present some important perspectives that emerged from this meeting.
Details
- Title: Subtitle
- Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
- Creators
- Joel L Berry - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at BirminghamWuqiang Zhu - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at BirminghamYao Liang Tang - Vascular Biology Center, Medical College of Georgia, Augusta University (Y.T.)Prasanna Krishnamurthy - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at BirminghamYing Ge - Department of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.)John P Cooke - Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.)Yabing Chen - Department of Pathology (Y.C., N.S.R.), University of Alabama at BirminghamDaniel J Garry - Lillehei Heart Institute, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis (D.J.G.)Huang-Tian Yang - Shanghai Institutes for Biological Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), China (H.-T.Y.)Namakkal Soorapan Rajasekaran - Department of Pathology (Y.C., N.S.R.), University of Alabama at BirminghamWalter J Koch - Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (W.J.K.)Song Li - Department of Bioengineering, University of California at Los Angeles (S.L.)Keitaro Domae - Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Japan (K.D.)Gangjian Qin - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at BirminghamKe Cheng - Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (K.C.)Timothy J Kamp - Department of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.)Lei Ye - National Heart Research Institute Singapore, National Heart Centre Singapore (L.Y.)Shijun Hu - Institute for Cardiovascular Science, Medical College of Soochow University, Suzhou, China (S.H.)Brenda M Ogle - Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN (B.M.O.)Jack M Rogers - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at BirminghamE Dale Abel - Division of Endocrinology and Metabolism, Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine (E.D.A.)Michael E Davis - Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory University School of Medicine, Atlanta (M.E.D.)Sumanth D Prabhu - Division of Cardiovascular Disease and Comprehensive Cardiovascular Center, Department of Medicine (S.D.P.), University of Alabama at BirminghamRonglih Liao - Stanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.)William T Pu - Department of Cardiology, Boston Children's Hospital, MA (W.T.P.)Yibin Wang - Department of Anesthesiology and Medicine (Y.W.), David Geffen School of Medicine, University of California, Los AngelesPeipei Ping - Department of Physiology (P.P.), David Geffen School of Medicine, University of California, Los AngelesNenad Bursac - Department of Biomedical Engineering, Duke University, Durham, NC (N.B.)Gordana Vunjak-Novakovic - Department of Biomedical Engineering and Department of Medicine, Columbia University, New York City, NY (G.V.-N.)Joseph C Wu - Stanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.)Roberto Bolli - Institute of Molecular Cardiology, Department of Medicine, University of Louisville, KY (R.B.)Philippe Menasché - Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Paris, France (P.M.)Jianyi Zhang - From the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.124(1), pp.161-169
- Publisher
- United States
- DOI
- 10.1161/CIRCRESAHA.118.314216
- PMID
- 30605412
- PMCID
- PMC6350935
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Grant note
- U01 HL134764 / NHLBI NIH HHS R01 HL118067 / NHLBI NIH HHS R01 HL137093 / NHLBI NIH HHS R01 HL129798 / NHLBI NIH HHS R01 HL136165 / NHLBI NIH HHS R01 HL123920 / NHLBI NIH HHS R01 HL114120 / NHLBI NIH HHS R01 HL086555 / NHLBI NIH HHS R01 HL131017 / NHLBI NIH HHS R56 HL142627 / NHLBI NIH HHS R13 HL147533 / NHLBI NIH HHS U01 HL099997 / NHLBI NIH HHS R01 AR070029 / NIAMS NIH HHS IK6 BX003617 / BLRD VA R01 HL076485 / NHLBI NIH HHS R01 HL148599 / NHLBI NIH HHS R01 HL137204 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/04/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024502102771
Metrics
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