Journal article
Converted neural cells: induced to a cure?
Protein & cell, Vol.3(2), pp.91-97
02/2012
DOI: 10.1007/s13238-012-2029-2
PMCID: PMC4104580
PMID: 22410787
Abstract
Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many groups were able to generate neural cells, either differentiated from induced pluripotent stem cells (iPSCs) or converted from somatic cells. Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs. In addition, the converted neural cells also hold the promise for cell replacement therapy (Kikuchi et al., 2011; Krencik et al., 2011; Kriks et al., 2011; Nori et al., 2011; Rhee et al., 2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives.
Details
- Title: Subtitle
- Converted neural cells: induced to a cure?
- Creators
- Weiqi Zhang - Beijing, 100101 ChinaShunlei Duan - Beijing, 100101 ChinaYing Li - Chinese Academy of SciencesXiuling Xu - Beijing, 100101 ChinaJing Qu - Beijing, 100101 ChinaWeizhou Zhang - San Diego, La Jolla, CA 92093 USAGuang-Hui Liu - Beijing, 100101 China
- Resource Type
- Journal article
- Publication Details
- Protein & cell, Vol.3(2), pp.91-97
- Publisher
- Higher Education Press
- DOI
- 10.1007/s13238-012-2029-2
- PMID
- 22410787
- PMCID
- PMC4104580
- ISSN
- 1674-800X
- eISSN
- 1674-8018
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984083871102771
Metrics
20 Record Views