Journal article
Co‐occurrence of orofacial clefts and clubfoot phenotypes in a sub‐Saharan African cohort: Whole‐exome sequencing implicates multiple syndromes and genes
Molecular genetics & genomic medicine, Vol.9(4), pp.e1655-n/a
03/14/2021
DOI: 10.1002/mgg3.1655
PMCID: PMC8123728
PMID: 33719213
Abstract
Whole‐exome sequencing was applied to hunt for possible etiologic variants in six individuals that presented with orofacial clefts and clubfoot. Our genomics and bioinformatics analyses revealed many genetic syndromes in four out of the six probands, with multiple variants in genes associated with certain genetic syndromes being observed in some probands.
Details
- Title: Subtitle
- Co‐occurrence of orofacial clefts and clubfoot phenotypes in a sub‐Saharan African cohort: Whole‐exome sequencing implicates multiple syndromes and genes
- Creators
- Lord J. J. Gowans - Kwame Nkrumah University of Science and TechnologyNoura Al Dhaheri - University of BaltimoreMary Li - University of IowaTamara Busch - University of IowaSolomon Obiri‐Yeboah - Kwame Nkrumah University of Science and TechnologyAlexander A. Oti - Kwame Nkrumah University of Science and TechnologyDaniel K. Sabbah - Kwame Nkrumah University of Science and TechnologyFareed K. N. Arthur - Kwame Nkrumah University of Science and TechnologyWaheed O. Awotoye - University of IowaAzeez A. Alade - University of IowaPeter Twumasi - Kwame Nkrumah University of Science and TechnologyPius Agbenorku - Kwame Nkrumah University of Science and TechnologyGyikua Plange‐Rhule - Kwame Nkrumah University of Science and TechnologyThirona Naicker - University of KwaZulu-NatalPeter Donkor - Kwame Nkrumah University of Science and TechnologyJeffrey C. Murray - University of IowaNara L. M. Sobreira - John Hopkins UniversityAzeez Butali - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Molecular genetics & genomic medicine, Vol.9(4), pp.e1655-n/a
- DOI
- 10.1002/mgg3.1655
- PMID
- 33719213
- PMCID
- PMC8123728
- NLM abbreviation
- Mol Genet Genomic Med
- ISSN
- 2324-9269
- eISSN
- 2324-9269
- Publisher
- John Wiley and Sons Inc
- Grant note
- 72429 / ; R00 DE022378; K43DE029427 / ; R37 DE‐08559 / ;
- Alternative title
- GOWANS et al
- Language
- English
- Date published
- 03/14/2021
- Academic Unit
- Oral Pathology, Radiology and Medicine; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984353832602771
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