Cooperation and heterogeneity of the autistic mind

Wako Yoshida; Isabel Dziobek; Dorit Kliemann; Hauke R Heekeren; Karl J Friston; Ray J Dolan

doi:10.1523/JNEUROSCI.0400-10.2010

Back

Cooperation and heterogeneity of the autistic mind

Journal article

Open access

Peer reviewed

Cooperation and heterogeneity of the autistic mind

Wako Yoshida, Isabel Dziobek, Dorit Kliemann, Hauke R Heekeren, Karl J Friston and Ray J Dolan

The Journal of neuroscience, Vol.30(26), pp.8815-8818

06/30/2010

DOI: 10.1523/JNEUROSCI.0400-10.2010

PMCID: PMC2907513

PMID: 20592203

Files and links (1)

url

https://doi.org/10.1523/JNEUROSCI.0400-10.2010View

Published (Version of record) Open Access

Abstract

Individuals with autism spectrum conditions (ASCs) have a core difficulty in recursively inferring the intentions of others. The precise cognitive dysfunctions that determine the heterogeneity at the heart of this spectrum, however, remains unclear. Furthermore, it remains possible that impairment in social interaction is not a fundamental deficit but a reflection of deficits in distinct cognitive processes. To better understand heterogeneity within ASCs, we employed a game-theoretic approach to characterize unobservable computational processes implicit in social interactions. Using a social hunting game with autistic adults, we found that a selective difficulty representing the level of strategic sophistication of others, namely inferring others' mindreading strategy, specifically predicts symptom severity. In contrast, a reduced ability in iterative planning was predicted by overall intellectual level. Our findings provide the first quantitative approach that can reveal the underlying computational dysfunctions that generate the autistic "spectrum."

Computers

Severity of Illness Index

Intelligence

Humans

Memory

Models, Psychological

Probability

Male

Autistic Disorder - psychology

Intelligence Tests

Game Theory

Psychiatric Status Rating Scales

Social Perception

Adult

Female

Autistic Disorder - diagnosis

Theory of Mind

Executive Function

Details

Title: Subtitle: Cooperation and heterogeneity of the autistic mind
Creators: Wako Yoshida - The Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom. w.yoshida@fil.ion.ucl.ac.uk
Isabel Dziobek
Dorit Kliemann
Hauke R Heekeren
Karl J Friston
Ray J Dolan
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.30(26), pp.8815-8818
Publisher: United States
DOI: 10.1523/JNEUROSCI.0400-10.2010
PMID: 20592203
PMCID: PMC2907513
ISSN: 0270-6474
eISSN: 1529-2401
Grant note: 078865 / Wellcome Trust 056750 / Wellcome Trust Wellcome Trust
Language: English
Date published: 06/30/2010
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065823502771

Metrics

11 Record Views

76 Times Cited - Web of Science

See more details