Journal article
Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation
Journal of leukocyte biology, Vol.78(1), pp.80-84
07/2005
DOI: 10.1189/jlb.1104669
PMID: 15899982
Abstract
It has been demonstrated previously that platelet-derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154(-/-) mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet-derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen-specific CD4(+) T cell numbers are limiting. We propose that in the physiologic setting where antigen-specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity.
Details
- Title: Subtitle
- Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation
- Creators
- Bennett D Elzey - Department of Urology, Iowa City, IA 52242, USAJulieann F GrantHaley W SinnBernhard NieswandtThomas J WaldschmidtTimothy L Ratliff
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.78(1), pp.80-84
- Publisher
- United States
- DOI
- 10.1189/jlb.1104669
- PMID
- 15899982
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Grant note
- A096691 / PHS HHS T32 GM007337 / NIGMS NIH HHS AI60924 / NIAID NIH HHS
- Language
- English
- Date published
- 07/2005
- Academic Unit
- Pathology; Urology
- Record Identifier
- 9984046905202771
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