Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi

Puja Shahi; W Scott Moye-Rowley

doi:10.1016/j.bbapap.2008.12.012

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Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi

Journal article

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Peer reviewed

Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi

Puja Shahi and W Scott Moye-Rowley

Biochimica et biophysica acta, Vol.1794(5), pp.852-859

05/2009

DOI: 10.1016/j.bbapap.2008.12.012

PMCID: PMC2671576

PMID: 19150512

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https://www.ncbi.nlm.nih.gov/pmc/articles/2671576View

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Abstract

Pathogenic fungi present a special problem in the clinic as the range of drugs that can be used to treat these types of infections is limited. This situation is further complicated by the presence of robust inducible gene networks encoding different proteins that confer tolerance to many available antifungal drugs. The transcriptional control of these multidrug resistance systems in several key fungi will be discussed. Experiments in the non-pathogenic Saccharomyces cerevisiae have provided much of our current understanding of the molecular framework on which fungal multidrug resistance is built. More recent studies on the important pathogenic Candida species, Candida albicans and Candida glabrata, have provided new insights into the organization of the multidrug resistance systems in these organisms. We will compare the circuitry of multidrug resistance networks in these three organisms and suggest that, in addition to the well-accepted drug efflux activities, the regulation of membrane composition by multidrug resistance proteins provides an important contribution to the resistant phenotypes observed.

Transcription, Genetic - drug effects

DNA-Binding Proteins - physiology

Transcription Factors - physiology

Saccharomyces cerevisiae - genetics

Sphingolipids - metabolism

Drug Resistance, Multiple, Fungal - physiology

ATP-Binding Cassette Transporters - physiology

Candida albicans - genetics

Lipids - chemistry

Genes, Fungal - drug effects

Saccharomyces cerevisiae Proteins - physiology

Phospholipids - metabolism

ATP Binding Cassette Transporter, Sub-Family B - genetics

Details

Title: Subtitle: Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi
Creators: Puja Shahi - Department of Molecular Physiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
W Scott Moye-Rowley
Resource Type: Journal article
Publication Details: Biochimica et biophysica acta, Vol.1794(5), pp.852-859
DOI: 10.1016/j.bbapap.2008.12.012
PMID: 19150512
PMCID: PMC2671576
NLM abbreviation: Biochim Biophys Acta
ISSN: 0006-3002
eISSN: 1878-2434
Publisher: Netherlands
Grant note: GM75120 / NIGMS NIH HHS R01 GM049825-13A2 / NIGMS NIH HHS R01 GM075120-02 / NIGMS NIH HHS R01 GM049825 / NIGMS NIH HHS GM49825 / NIGMS NIH HHS R01 GM075120 / NIGMS NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Molecular Physiology and Biophysics; Internal Medicine
Record Identifier: 9984025582302771

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