Coordinate enhancers share common organizational features in the Drosophila genome

Albert Erives; Michael Levine

doi:10.1073/pnas.0400611101

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Coordinate enhancers share common organizational features in the Drosophila genome

Journal article

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Coordinate enhancers share common organizational features in the Drosophila genome

Albert Erives and Michael Levine

Proceedings of the National Academy of Sciences - PNAS, Vol.101(11), pp.3851-3856

03/16/2004

DOI: 10.1073/pnas.0400611101

PMCID: PMC374333

PMID: 15026577

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Abstract

The evolution of animal diversity depends on changes in the regulation of a relatively fixed set of protein-coding genes. To understand how these changes might arise, we examined the organization of shared sequence motifs in four coordinately regulated neurogenic enhancers that direct similar patterns of gene expression in the early Drosophila embryo. All four enhancers possess similar arrangements of a subset of putative regulatory elements. These shared features were used to identify a neurogenic enhancer in the distantly related Anopheles genome. We suggest that the constrained organization of metazoan enhancers may be essential for their ability to produce precise patterns of gene expression during development. Organized binding sites should facilitate the identification of regulatory codes that link primary DNA sequence information with predicted patterns of gene activity.

Biological Sciences

Details

Title: Subtitle: Coordinate enhancers share common organizational features in the Drosophila genome
Creators: Albert Erives - Center for Integrative Genomics, Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720
Michael Levine - Center for Integrative Genomics, Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.101(11), pp.3851-3856
DOI: 10.1073/pnas.0400611101
PMID: 15026577
PMCID: PMC374333
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 03/16/2004
Academic Unit: Biology
Record Identifier: 9984217532802771

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