Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Kesia Esther Silva; Rodrigo Cayô; Cecilia Godoy Carvalhaes; Flávia Patussi Correia Sacchi; Fernanda Rodrigues-Costa; Ana Carolina Ramos da Silva; Julio Croda; Ana Cristina Gales; Simone Simionatto

doi:10.1128/JCM.00727-15

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Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Journal article

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Peer reviewed

Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Kesia Esther Silva, Rodrigo Cayô, Cecilia Godoy Carvalhaes, Flávia Patussi Correia Sacchi, Fernanda Rodrigues-Costa, Ana Carolina Ramos da Silva, Julio Croda, Ana Cristina Gales and Simone Simionatto

Journal of clinical microbiology, Vol.53(7), pp.2324-2328

07/2015

DOI: 10.1128/JCM.00727-15

PMCID: PMC4473237

PMID: 25878341

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Abstract

We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The blaIMP-10 gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to blaKPC-2.

Adult

Aged

Aged, 80 and over

Anti-Bacterial Agents - pharmacology

beta-Lactam Resistance

beta-Lactamases - genetics

beta-Lactamases - secretion

Brazil - epidemiology

Carbapenems - pharmacology

Child, Preschool

Cross Infection - epidemiology

Cross Infection - microbiology

Disease Outbreaks

DNA, Bacterial - genetics

Female

Genes, Bacterial

Hospitals, Teaching

Humans

Infant

Integrons

Male

Microbial Sensitivity Tests

Middle Aged

Minocycline - analogs & derivatives

Minocycline - pharmacology

Molecular Sequence Data

Plasmids

Sequence Analysis, DNA

Serratia Infections - epidemiology

Serratia Infections - microbiology

Serratia marcescens - drug effects

Serratia marcescens - enzymology

Serratia marcescens - isolation & purification

Details

Title: Subtitle: Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital
Creators: Kesia Esther Silva - Universidade Federal da Grande Dourados
Rodrigo Cayô - Universidade Federal de São Paulo
Cecilia Godoy Carvalhaes - Universidade Federal de São Paulo
Flávia Patussi Correia Sacchi - Universidade Federal da Grande Dourados
Fernanda Rodrigues-Costa - Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
Ana Carolina Ramos da Silva - Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
Julio Croda - Universidade Federal da Grande Dourados
Ana Cristina Gales - Universidade Federal de São Paulo
Simone Simionatto - Universidade Federal da Grande Dourados
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.53(7), pp.2324-2328
DOI: 10.1128/JCM.00727-15
PMID: 25878341
PMCID: PMC4473237
ISSN: 0095-1137
eISSN: 1098-660X
Language: English
Date published: 07/2015
Academic Unit: Pathology
Record Identifier: 9984185165202771

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