Core muscle characteristics during walking of patients with multiple sclerosis

Nathaniel B Ketelhut; John H Kindred; Mark M Manago; Jeffrey R Hebert; Thorsten Rudroff

doi:10.1682/JRRD.2015.01.0006

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Core muscle characteristics during walking of patients with multiple sclerosis

Journal article

Open access

Peer reviewed

Core muscle characteristics during walking of patients with multiple sclerosis

Nathaniel B Ketelhut, John H Kindred, Mark M Manago, Jeffrey R Hebert and Thorsten Rudroff

Journal of rehabilitation research and development, Vol.52(6), pp.713-724

2015

DOI: 10.1682/JRRD.2015.01.0006

PMID: 26562753

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Abstract

The purpose of this study was to investigate core muscle characteristics during walking in patients with multiple sclerosis (MS). Eight patients (4 men) with relapsing-remitting MS (aged 44.9 +/- 8.6 yr) and sex-matched controls (37.9 +/- 8.4 yr) walked on a treadmill for 15 min at a self-selected speed. Positron emission tomography/computed tomography imaging was used to measure core muscle activity immediately after walking based on glucose uptake. Activity was not different between the MS and control group for any of the identified muscles (p > 0.28). Within the MS group, side differences in activity were identified in the lateral flexor group, the external and internal obliques, and the rectus abdominis (p < 0.05), with the less-affected side being activated more. Furthermore, greater muscle volume was found on the more-affected side of the transversus abdominis, quadratus lumborum, and the low-back extensor group (p < 0.03). These muscle characteristics suggest patients with MS utilize compensatory mechanisms during walking to maintain balance and posture. These strategies likely result in increased muscle energy cost and early fatigability.

Humans

Middle Aged

Organ Size

Male

Tomography, X-Ray Computed

Multiple Sclerosis, Relapsing-Remitting - physiopathology

Positron-Emission Tomography

Case-Control Studies

Walking - physiology

Multimodal Imaging

Rectus Abdominis - physiopathology

Posture - physiology

Muscle, Skeletal - physiopathology

Glucose - metabolism

Adult

Female

Fluorodeoxyglucose F18

Postural Balance - physiology

Muscle, Skeletal - pathology

Radiopharmaceuticals

Rectus Abdominis - pathology

Details

Title: Subtitle: Core muscle characteristics during walking of patients with multiple sclerosis
Creators: Nathaniel B Ketelhut - Department of Health and Exercise Science, Colorado State University, Fort Collins, CO
John H Kindred
Mark M Manago
Jeffrey R Hebert
Thorsten Rudroff
Resource Type: Journal article
Publication Details: Journal of rehabilitation research and development, Vol.52(6), pp.713-724
DOI: 10.1682/JRRD.2015.01.0006
PMID: 26562753
NLM abbreviation: J Rehabil Res Dev
ISSN: 0748-7711
eISSN: 1938-1352
Publisher: United States
Grant note: UL1 TR000154 / NCATS NIH HHS
Language: English
Date published: 2015
Academic Unit: Neurology; Health, Sport, and Human Physiology
Record Identifier: 9984001106002771

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