Journal article
Core promoter elements can regulate transcription on a separate chromosome in trans
Genes & development, Vol.13(3), pp.253-258
02/01/1999
DOI: 10.1101/gad.13.3.253
PMCID: PMC316431
PMID: 9990850
Abstract
Transvection can cause the expression of a gene to be sensitive to the proximity of a homolog. It can account for many cases of intragenic complementation at the
Drosophila yellow
gene, where one mode of transvection involves the action of enhancers in
trans
on a promoter present on a separate chromosome. Our goal was to identify
cis
-acting elements that regulate the
trans
action of enhancers. Using gene replacement, we altered two core promoter elements at
yellow
and tested the resulting alleles for their ability to support transvection. We found that the TATA box and initiator element can regulate transvection.
Details
- Title: Subtitle
- Core promoter elements can regulate transcription on a separate chromosome in trans
- Creators
- James R Morris - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USAPamela K Geyer - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USAChao-ting Wu - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.13(3), pp.253-258
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/gad.13.3.253
- PMID
- 9990850
- PMCID
- PMC316431
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Language
- English
- Date published
- 02/01/1999
- Academic Unit
- Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984024531002771
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