Corneal transplant survival after onset of severe endothelial rejection

Michael D Wagoner; Rola Ba-Abbad; John E Sutphin; M Bridget Zimmerman

doi:10.1016/j.ophtha.2006.12.012

Back

Corneal transplant survival after onset of severe endothelial rejection

Journal article

Peer reviewed

Corneal transplant survival after onset of severe endothelial rejection

Michael D Wagoner, Rola Ba-Abbad, John E Sutphin and M Bridget Zimmerman

Ophthalmology (Rochester, Minn.), Vol.114(9), pp.1630-1636.e1

09/2007

DOI: 10.1016/j.ophtha.2006.12.012

PMID: 17367863

View Online

Abstract

To evaluate corneal graft survival after onset of severe endothelial rejection after penetrating keratoplasty (PK). Retrospective case series. One hundred fifty-six patients (161 PKs) treated at a single center. Retrospective review of the medical records of every case of severe endothelial rejection admitted to the King Khaled Eye Specialist Hospital (KKESH) between January 1, 1998 and December 31, 2002. Patients for whom PK had been performed at KKESH between June 1, 1983 and December 31, 2002 and in whom at least 3 months of follow-up was available were included in the statistical analysis. Graft survival. One hundred fifty-seven PKs (152 patients) met the inclusion criteria and were included in the statistical analysis. Four PKs (4 patients) were excluded from the statistical analysis due to inadequate follow-up. The rejection episode was reversed during the first 3 months in 90 grafts (57.3%). By Kaplan-Meier analysis, graft survivals were 42.6% at 1 year and 36.1% at 3 years. The surgical indication for PK significantly correlated with likelihood of reversibility (P<0.001) and long-term graft survival (P<0.001). Risk factors associated with an increased risk of postrejection graft failure included increasing donor age (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.04-1.24; P = 0.004), increasing patient age (OR, 1.23; 95% CI, 1.11-1.35; P<0.001), and history of rejection episodes (P = 0.002). Endothelial rejection is a serious complication of PK, with a high risk of graft failure.

Glucocorticoids - administration & dosage

Prednisolone - administration & dosage

Humans

Middle Aged

Child, Preschool

Infant

Male

Endothelium, Corneal - pathology

Prednisolone - analogs & derivatives

Time Factors

Aged, 80 and over

Adult

Female

Retrospective Studies

Child

Keratoplasty, Penetrating - adverse effects

Graft Rejection - drug therapy

Graft Rejection - physiopathology

Risk Factors

Graft Rejection - etiology

Adolescent

Graft Survival - physiology

Aged

Cornea - physiopathology

Administration, Topical

Details

Title: Subtitle: Corneal transplant survival after onset of severe endothelial rejection
Creators: Michael D Wagoner - Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. mwagoner@kkesh.med.sa
Rola Ba-Abbad
John E Sutphin
M Bridget Zimmerman
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.114(9), pp.1630-1636.e1
Publisher: United States
DOI: 10.1016/j.ophtha.2006.12.012
PMID: 17367863
ISSN: 0161-6420
eISSN: 1549-4713
Language: English
Date published: 09/2007
Academic Unit: Biostatistics; Ophthalmology and Visual Sciences
Record Identifier: 9983980289602771

Metrics

24 Record Views

25 Times Cited - Web of Science