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Corollary discharge in precerebellar nuclei of sleeping infant rats
Journal article   Open access   Peer reviewed

Corollary discharge in precerebellar nuclei of sleeping infant rats

Didhiti Mukherjee, Greta Sokoloff and Mark S Blumberg
eLife, Vol.7, e38213
12/05/2018
DOI: 10.7554/eLife.38213
PMCID: PMC6281370
PMID: 30516134
url
https://doi.org/10.7554/eLife.38213View
Published (Version of record) Open Access

Abstract

In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send motor copies (or corollary discharge, CD) to the cerebellum. We tested this possibility by recording from two precerebellar nuclei-the inferior olive (IO) and lateral reticular nucleus (LRN). In most IO and LRN neurons, twitch-related activity peaked sharply around twitch onset, consistent with CD. Next, we identified twitch-production areas in the midbrain that project independently to the IO and LRN. Finally, we blocked calcium-activated slow potassium (SK) channels in the IO to explain how broadly tuned brainstem motor signals can be transformed into precise CD signals. We conclude that the precerebellar nuclei convey a diversity of sleep-related neural activity to the developing cerebellum to enable processing of convergent input from CD and reafferent signals.
 Animals, Newborn Motor Activity - physiology Potassium Channels, Voltage-Gated - physiology Synaptic Transmission - physiology Brain Stem - anatomy & histology Cerebellar Nuclei - cytology Rats Male Muscle, Skeletal - innervation Neurons - cytology Muscle, Skeletal - physiology Brain Stem - cytology Brain Stem - physiology Rats, Sprague-Dawley Animals Cerebellar Nuclei - anatomy & histology Neurons - physiology Female Cerebellar Nuclei - physiology Sleep - physiology

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