Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus

Samuel R Schnittman; Douglas W Kitch; Talia H Swartz; Tricia H Burdo; Kathleen V Fitch; Sara McCallum; Jacqueline M Flynn; Evelynne S Fulda; Marissa R Diggs; Jack T Stapleton; José L Casado; Jana Taron; Judith S Currier; Markella V Zanni; Carlos Malvestutto; Carl J Fichtenbaum; Judith A Aberg; Heather J Ribaudo; Michael T Lu; Pamela S Douglas; Steven K Grinspoon

doi:10.1093/ofid/ofad106

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Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus

Journal article

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Peer reviewed

Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus

Samuel R Schnittman, Douglas W Kitch, Talia H Swartz, Tricia H Burdo, Kathleen V Fitch, Sara McCallum, Jacqueline M Flynn, Evelynne S Fulda, Marissa R Diggs, Jack T Stapleton, …

Open forum infectious diseases, Vol.10(3), ofad106

03/01/2023

DOI: 10.1093/ofid/ofad106

PMCID: PMC10043127

PMID: 36998633

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Abstract

Among ART-treated people with HIV at low-moderate traditional cardiovascular disease risk, inflammasome activation markers were associated with Leaman score, a composite index of plaque burden and severity, which has been associated with major cardiovascular events in the general population.

AcademicSubjects

atherosclerosis

Brief Report

HIV

inflammasome

Leaman score

MED00290

Details

Title: Subtitle: Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus
Creators: Samuel R Schnittman - Massachusetts General Hospital
Douglas W Kitch - Cancer Research And Biostatistics
Talia H Swartz - Icahn School of Medicine at Mount Sinai
Tricia H Burdo - Temple University
Kathleen V Fitch - Massachusetts General Hospital
Sara McCallum - Massachusetts General Hospital
Jacqueline M Flynn - Temple University
Evelynne S Fulda - Massachusetts General Hospital
Marissa R Diggs - Massachusetts General Hospital
Jack T Stapleton - University of Iowa
José L Casado - Department of Infectious Diseases, Ramon y Cajal Health Research Institute (IRyCIS), University Hospital Ramon y Cajal , Madrid , Spain
Jana Taron - University of Freiburg
Judith S Currier - University of California, Los Angeles
Markella V Zanni - Massachusetts General Hospital
Carlos Malvestutto - The Ohio State University Wexner Medical Center
Carl J Fichtenbaum - University of Cincinnati
Judith A Aberg - Icahn School of Medicine at Mount Sinai
Heather J Ribaudo - Cancer Research And Biostatistics
Michael T Lu - Massachusetts General Hospital
Pamela S Douglas - Duke University
Steven K Grinspoon - Massachusetts General Hospital
Resource Type: Journal article
Publication Details: Open forum infectious diseases, Vol.10(3), ofad106
DOI: 10.1093/ofid/ofad106
PMID: 36998633
PMCID: PMC10043127
NLM abbreviation: Open Forum Infect Dis
ISSN: 2328-8957
eISSN: 2328-8957
Publisher: Oxford University Press
Grant note: ; UM1 AI068636; UM1 AI106701; T32 AI007387; R01 DA052255; R21 AI152833; R01 HL141132; K24 AI57882; P30 DK40561 / ; U01HL123336; U01HL123339 / ;
Language: English
Date published: 03/01/2023
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984381023102771

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