Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase

G F Wu; L Pewe; S Perlman

doi:10.1128/JVI.74.16.7683-7686.2000

Back

Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase

Journal article

Open access

Peer reviewed

Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase

G F Wu, L Pewe and S Perlman

Journal of virology, Vol.74(16), pp.7683-7686

08/2000

DOI: 10.1128/JVI.74.16.7683-7686.2000

PMCID: PMC112293

PMID: 10906226

Files and links (1)

url

https://europepmc.org/articles/pmc112293View

Published (Version of record) Open Access

Abstract

Demyelination induced by mouse hepatitis virus (MHV), strain JHM, is in large part immune mediated, but little is known about the mechanisms involved in this process. Previous results suggest that inducible nitric oxide synthase (NOS2) contributes transiently to MHV-induced demyelination. Herein, we show that equivalent amounts of demyelination were evident at day 12 after MHV infection in mice genetically deficient in NOS2 (NOS2(-/-)) and in C57BL/6 mice. Furthermore, using an established adoptive transfer model and pharmacological inhibitors of NOS2 function, we could demonstrate no effect on MHV-induced demyelination. These results indicate that NOS2 function is not required for demyelination in mice infected with MHV.

Demyelinating Diseases - virology

Mice, Inbred C57BL

Nitric Oxide Synthase - antagonists & inhibitors

Adoptive Transfer

Murine hepatitis virus - pathogenicity

Nitric Oxide Synthase - genetics

Nitric Oxide Synthase Type II

Murine hepatitis virus - isolation & purification

Animals

Coronavirus Infections - virology

Spinal Cord - pathology

Coronavirus Infections - pathology

Mice

Nitric Oxide Synthase - metabolism

Demyelinating Diseases - pathology

Details

Title: Subtitle: Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase
Creators: G F Wu - Program in Neuroscience, University of Iowa, Iowa City, Iowa 52242, USA
L Pewe
S Perlman
Resource Type: Journal article
Publication Details: Journal of virology, Vol.74(16), pp.7683-7686
DOI: 10.1128/JVI.74.16.7683-7686.2000
PMID: 10906226
PMCID: PMC112293
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: F30 MH012066 / NIMH NIH HHS MH12066-02 / NIMH NIH HHS NS36592 / NINDS NIH HHS R01 NS036592 / NINDS NIH HHS
Language: English
Date published: 08/2000
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777347902771

Metrics

23 Record Views

25 Times Cited - Web of Science