Coronaviruses: An Updated Overview of Their Replication and Pathogenesis

Yuhang Wang; Matthew Grunewald; Stanley Perlman

doi:10.1007/978-1-0716-0900-2_1

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Coronaviruses: An Updated Overview of Their Replication and Pathogenesis

Journal article

Open access

Coronaviruses: An Updated Overview of Their Replication and Pathogenesis

Yuhang Wang, Matthew Grunewald and Stanley Perlman

Methods in molecular biology (Clifton, N.J.), Vol.2203, pp.1-29

2020

DOI: 10.1007/978-1-0716-0900-2_1

PMCID: PMC7682345

PMID: 32833200

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https://doi.org/10.1007/978-1-0716-0900-2_1View

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Abstract

Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. CoVs cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs, and upper respiratory tract and kidney disease in chickens to lethal human respiratory infections. Most recently, the novel coronavirus, SARS-CoV-2, which was first identified in Wuhan, China in December 2019, is the cause of a catastrophic pandemic, COVID-19, with more than 8 million infections diagnosed worldwide by mid-June 2020. Here we provide a brief introduction to CoVs discussing their replication, pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), which are relevant for understanding COVID-19.

Animal Diseases - prevention & control

Betacoronavirus - pathogenicity

Coronavirus Infections - prevention & control

Severe Acute Respiratory Syndrome - epidemiology

Severe Acute Respiratory Syndrome - virology

Humans

Pandemics - prevention & control

Chickens - virology

Severe Acute Respiratory Syndrome - diagnosis

COVID-19

SARS-CoV-2

SARS Virus - genetics

Coronavirus Infections - epidemiology

Pneumonia, Viral - epidemiology

Virion

Cattle

Swine

Betacoronavirus - physiology

SARS Virus - physiology

Coronavirus - physiology

Coronavirus - pathogenicity

Spike Glycoprotein, Coronavirus - genetics

Coronavirus Infections - diagnosis

Animal Diseases - diagnosis

Animal Diseases - virology

SARS Virus - pathogenicity

Animal Diseases - epidemiology

Middle East Respiratory Syndrome Coronavirus - pathogenicity

Severe Acute Respiratory Syndrome - prevention & control

Animals

Coronavirus Infections - virology

Virus Replication

Middle East Respiratory Syndrome Coronavirus - genetics

Pneumonia, Viral - prevention & control

Coronavirus - genetics

Pneumonia, Viral - diagnosis

Betacoronavirus - genetics

Pneumonia, Viral - virology

Middle East Respiratory Syndrome Coronavirus - physiology

Details

Title: Subtitle: Coronaviruses: An Updated Overview of Their Replication and Pathogenesis
Creators: Yuhang Wang - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Matthew Grunewald - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA
Stanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. stanley-perlman@uiowa.edu
Resource Type: Journal article
Publication Details: Methods in molecular biology (Clifton, N.J.), Vol.2203, pp.1-29
DOI: 10.1007/978-1-0716-0900-2_1
PMID: 32833200
PMCID: PMC7682345
NLM abbreviation: Methods Mol Biol
eISBN: 1071609009; 9781071609002
ISSN: 1064-3745
eISSN: 1940-6029
Publisher: United States
Grant note: R01 AI129269 / NIAID NIH HHS P01 AI060699 / NIAID NIH HHS T32 GM007337 / NIGMS NIH HHS R01 NS036592 / NINDS NIH HHS
Language: English
Date published: 2020
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9984070162002771

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