Journal article
Coronaviruses: an overview of their replication and pathogenesis
Methods in molecular biology (Clifton, N.J.), Vol.1282, pp.1-23
2015
DOI: 10.1007/978-1-4939-2438-7_1
PMCID: PMC4369385
PMID: 25720466
Abstract
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
Details
- Title: Subtitle
- Coronaviruses: an overview of their replication and pathogenesis
- Creators
- Anthony R Fehr - Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USAStanley Perlman
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.1282, pp.1-23
- DOI
- 10.1007/978-1-4939-2438-7_1
- PMID
- 25720466
- PMCID
- PMC4369385
- NLM abbreviation
- Methods Mol Biol
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Publisher
- United States
- Grant note
- P01 AI060699 / NIAID NIH HHS R01 AI091322 / NIAID NIH HHS R01 NS036592 / NINDS NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777476102771
Metrics
206 Record Views