Journal article
Coronaviruses post-SARS: update on replication and pathogenesis
Nature reviews. Microbiology, Vol.7, pp.439-450
06/2009
DOI: 10.1038/nrmicro2147
PMCID: PMC2830095
PMID: 19430490
Abstract
Although coronaviruses were first identified nearly 60 years ago, they only received notoriety in 2003 when one of their members was identified as the aetiological agent of severe acute respiratory syndrome. Previously these viruses were known to be important agents of respiratory and enteric infections of domestic and companion animals and to cause approximately 15% of all cases of the common cold. This Review focuses on recent advances in our understanding of the mechanisms of coronavirus replication, interactions with the host immune response and disease pathogenesis. It also highlights the recent identification of numerous novel coronaviruses and the propensity of this virus family to cross species barriers.
Details
- Title: Subtitle
- Coronaviruses post-SARS: update on replication and pathogenesis
- Creators
- Stanley Perlman - Department of Microbiology and Interdisciplinary Program in Immunology, University of Iowa, Iowa City, 52242, USA. stanley-perlman@uiowa.eduJason Netland
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Microbiology, Vol.7, pp.439-450
- DOI
- 10.1038/nrmicro2147
- PMID
- 19430490
- PMCID
- PMC2830095
- NLM abbreviation
- Nat Rev Microbiol
- ISSN
- 1740-1526
- eISSN
- 1740-1534
- Publisher
- England
- Grant note
- P01 AI060699-05 / NIAID NIH HHS R01 NS36592 / NINDS NIH HHS P01 AI060699 / NIAID NIH HHS R01 NS036592 / NINDS NIH HHS T32 AI007533 / NIAID NIH HHS
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777351802771
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