Journal article
Corpus callosal atrophy in premanifest and early Huntington's disease
Journal of Huntington's disease, Vol.2(4), pp.517-526
2013
DOI: 10.3233/JHD-130077
PMID: 25062736
Abstract
Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas.
To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks.
Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B <10.8 years from predicted onset), 84 early HD (53 Stage 1 (HD1) and 31 Stage 2 (HD2)) and 101 control subjects from the TRACK-HD study, using a semi-automated technique for CC delineation. Between-group differences in volume and 24-month atrophy rates, and correlations with cognitive performance were investigated using regression models, adjusting for potential confounders.
PreHD-B, HD1 and HD2 had statistically significantly smaller baseline CC volumes (p < 0.001) and all groups had elevated 24-month atrophy rates compared with controls (p < 0.001). Smaller baseline CC volume was associated with impaired performance in the Circle Tracing Indirect task in early HD (p < 0.05). Positive, non-statistically significant relationships with Stroop Word Reading were shown in both gene-positive groups. There was no evidence of an association with the Trail Making B task.
We found reduced CC volume and elevated 24-month atrophy rates, even in individuals far from disease onset. Structural degeneration of interhemispheric connections may contribute to cognitive deficits, such as performance in the Circle Tracing Indirect task in HD. Examination of different image acquisitions may provide more specific information about underlying CC degeneration.
Details
- Title: Subtitle
- Corpus callosal atrophy in premanifest and early Huntington's disease
- Creators
- Helen E Crawford - UCL Institute of Neurology, University College London, UKNicola Z Hobbs - UCL Institute of Neurology, University College London, UKRuth Keogh - Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UKDouglas R Langbehn - Departments of Psychiatry and Biostatistics (Secondary), University of Iowa, Iowa City, IA, USAChris Frost - Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UKHans Johnson - Department of Psychiatry, University of Iowa, Iowa City, IA, USABernhard Landwehrmeyer - Department of Neurology, Ulm University, Ulm, GermanyRalf Reilmann - Department of Neurology, University of Münster, Münster, GermanyDavid Craufurd - Institute of Human Development, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK and Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UKJulie C Stout - School of Psychology and Psychiatry, Monash University, VIC, AustraliaAlexandra Durr - Department of Genetics and Cytogenetics, and INSERM UMR S679, APHP Hôpital de la Salpêtrière, Paris, FranceBlair R Leavitt - Centre for Molecular Medicine & Therapeutics, Dept. of Medical Genetics, University of British Columbia, Vancouver, BC, CanadaRaymund A C Roos - Department of Neurology, Leiden University Medical Centre, Leiden, The NetherlandsSarah J Tabrizi - UCL Institute of Neurology, University College London, UKRachael I Scahill - UCL Institute of Neurology, University College London, UK
- Resource Type
- Journal article
- Publication Details
- Journal of Huntington's disease, Vol.2(4), pp.517-526
- Publisher
- Netherlands
- DOI
- 10.3233/JHD-130077
- PMID
- 25062736
- ISSN
- 1879-6397
- eISSN
- 1879-6400
- Language
- English
- Date published
- 2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066146302771
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