Journal article
Corpus callosum shape and size in male patients with schizophrenia
Biological psychiatry (1969), Vol.44(6), pp.405-412
1998
DOI: 10.1016/S0006-3223(98)00096-1
PMID: 9777169
Abstract
Background: Corpus callosum (CC) morphology has recently been investigated in schizophrenia using refined imaging and analytic techniques; however, methodological problems and small sample sizes have led to inconsistent findings.
Methods: This study used a large sample of male schizophrenics (
n = 79) and male controls (
n = 65) to investigate size and shape of the CC on midsagittal magnetic resonance images. Size was determined by tracing the area of the CC, and shape was determined using a landmark-based analysis. In addition, the relationship between CC morphology and phenomenologic variables such as age of onset, length of illness, exposure to medications, and symptom severity was explored.
Results: After controlling for age, height, and parental socioeconomic status, there was a main effect of diagnosis on CC size (
F = 5.05, df = 1,139,
p < .03), with patients’ CCs being significantly smaller. No difference was found between patients and controls in CC shape (
F = 1.07, df = 18,125,
p > .38) or orientation (
F = 0.79, df = 18,125,
p > .70), using a landmark-based technique. Finally, there was a significant inverse correlation between size of CC and severity of negative symptoms.
Conclusions: These findings support previous studies that have found a decrease in size of the CC in patients with schizophrenia. Moreover, the decrement in volume is generalized, not regional, and is related to the severity of negative symptoms.
Details
- Title: Subtitle
- Corpus callosum shape and size in male patients with schizophrenia
- Creators
- Philip Tibbo - Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada (PT)Peg Nopoulos - Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, Iowa, USA (PN, SA, NCA)Stephan Arndt - Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, Iowa, USA (PN, SA, NCA)Nancy C Andreasen - Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, Iowa, USA (PN, SA, NCA)
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.44(6), pp.405-412
- DOI
- 10.1016/S0006-3223(98)00096-1
- PMID
- 9777169
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1998
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984003931202771
Metrics
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