Journal article
Corpus callosum size may predict late-life depression in women: A 10-year follow-up study
Journal of affective disorders, Vol.165, pp.16-23
08/20/2014
DOI: 10.1016/j.jad.2014.04.040
PMID: 24882172
Abstract
Recent research on late-life depression (LLD) pathophysiology suggests the implication of abnormalities in cerebral white matter and particularly in interhemispheric transfer. Corpus callosum (CC) is the main brain interhemispheric commissure. Hence, we investigated the association between baseline CC measures and risk of LDD.
We studied 467 non-demented individuals without LLD at baseline from a cohort of elderly community-dwelling people (the ESPRIT study). LLD was assessed at year 2, 4, 7 and 10 of the study follow-up. At baseline, T1-weighted magnetic resonance images were manually traced to measure the mid-sagittal areas of the anterior, mid and posterior CC. Multivariate Cox proportional hazards models stratified by sex were used to predict LLD incidence over 10 years.
A significant interaction between gender and CC size was found (p=0.02). LLD incidence in elderly women, but not in men, was significantly associated with smaller anterior (HR 1.37 [1.05–1.79] p=0.017), mid (HR 1.43 [1.09–1.86] p=0.008), posterior (HR 1.39 [1.12–1.74] p=0.002) and total (HR 1.53 [1.16–2.00] p=0.002) CC areas at baseline in Cox models adjusted for age, education, global cognitive impairment, ischemic pathologies, left-handedness, white matter lesion, intracranial volume and past depression.
The main limitation was the retrospective assessment of major depression.
Smaller CC size is a predictive factor of incident LLD over 10 years in elderly women independently of cognitive deterioration. Our finding suggests a possible role of CC and reduced interhemispheric connectivity in LLD pathophysiology. Extensive explorations are needed to clarify the mechanisms leading to CC morphometric changes in mood disorders.
Details
- Title: Subtitle
- Corpus callosum size may predict late-life depression in women: A 10-year follow-up study
- Creators
- Fabienne Cyprien - InsermPhilippe Courtet - InsermVanessa Poulain - InsermJerome Maller - Monash Alfred Psychiatry Research centreChantal Meslin - Australian National UniversityAlain Bonafé - Université de MontpellierEmmanuelle Le Bars - CHRU Montpellier, Montpellier, FranceMarie-Laure Ancelin - InsermKaren Ritchie - Centre Hospitalier Universitaire de MontpellierSylvaine Artero - Inserm
- Resource Type
- Journal article
- Publication Details
- Journal of affective disorders, Vol.165, pp.16-23
- DOI
- 10.1016/j.jad.2014.04.040
- PMID
- 24882172
- NLM abbreviation
- J Affect Disord
- ISSN
- 0165-0327
- eISSN
- 1573-2517
- Publisher
- Elsevier B.V
- Number of pages
- 8
- Language
- English
- Date published
- 08/20/2014
- Academic Unit
- Radiology
- Record Identifier
- 9984848505902771
Metrics
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