Correcting for Fat Mass Improves DXA Quantification of Quadriceps Specific Strength in Obese Adults Aged 50–59 Years

Neil A Segal; Natalie A Glass; Jennifer L Baker; James C Torner

doi:10.1016/j.jocd.2008.11.003

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Correcting for Fat Mass Improves DXA Quantification of Quadriceps Specific Strength in Obese Adults Aged 50–59 Years

Journal article

Peer reviewed

Correcting for Fat Mass Improves DXA Quantification of Quadriceps Specific Strength in Obese Adults Aged 50–59 Years

Neil A Segal, Natalie A Glass, Jennifer L Baker and James C Torner

Journal of clinical densitometry, Vol.12(3), pp.299-305

2009

DOI: 10.1016/j.jocd.2008.11.003

PMCID: PMC2906608

PMID: 19121597

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http://doi.org/10.1016/j.jocd.2008.11.003View

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Abstract

Dual-energy X-ray absorptiometry (DXA) is widely used for bone mineral density and body composition assessments. However, DXA is known to overestimate muscle mass in obese adults. We used single-slice CT (ssCT) to derive a correction factor to enhance accuracy of DXA estimation of specific strength (strength per unit muscle). One hundred and sixty-two adults (age: 55.0 ± 2.7 yr, range: 50–59) were enrolled in this cross-sectional study and divided into groups based on body mass index (BMI: <30, 30–35, and ≥35). BMI groups did not differ in age, knee extensor strength (KES), thigh lean mass by DXA, or quadriceps cross-sectional area (CSA) by ssCT. Specific strength (KES/CSA) correlated with an uncorrected estimate of DXA–specific strength ( r = 0.82, 0.53, 0.84 and 0.74, 0.59, 0.57, p < 0.001) in the lowest to highest BMI groups in men and women, respectively. Stronger correlations were achieved through correcting for BMI, age, and sex in estimating DXA—specific strength ( r = 0.81, 0.79, and 0.96 in the lowest to highest BMI groups in men and 0.94, 0.81, 0.85 in women, p < 0.0001). Quantification of knee extensor—specific strength by DXA in men with BMI >30 and all BMI groups in women greatly improved using a correction factor for DXA estimates of thigh lean mass.

dual-energy X-ray absorptiometry

knee extensor strength

fat-free mass

specific strength

obesity

Details

Title: Subtitle: Correcting for Fat Mass Improves DXA Quantification of Quadriceps Specific Strength in Obese Adults Aged 50–59 Years
Creators: Neil A Segal - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
Natalie A Glass - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
Jennifer L Baker - Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA
James C Torner - Department of Epidemiology, The University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: Journal of clinical densitometry, Vol.12(3), pp.299-305
DOI: 10.1016/j.jocd.2008.11.003
PMID: 19121597
PMCID: PMC2906608
NLM abbreviation: J Clin Densitom
ISSN: 1094-6950
eISSN: 1559-0747
Publisher: Elsevier Inc
Language: English
Date published: 2009
Academic Unit: Epidemiology; Orthopedics and Rehabilitation; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995030802771

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