Correlating thyroid cytology and histopathology: Implications for molecular testing

Michael J Reed; Steven M Sperry; Michael P Gailey; Chris S Jensen; Robert A Robinson; Gerry F Funk; Nitin A Pagedar

doi:10.1002/hed.24410

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Correlating thyroid cytology and histopathology: Implications for molecular testing

Journal article

Peer reviewed

Correlating thyroid cytology and histopathology: Implications for molecular testing

Michael J Reed, Steven M Sperry, Michael P Gailey, Chris S Jensen, Robert A Robinson, Gerry F Funk and Nitin A Pagedar

Head & neck, Vol.38(7), pp.1104-1106

07/2016

DOI: 10.1002/hed.24410

PMID: 26900030

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Abstract

A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings were recorded. Using published sensitivity and specificity, NPVs were calculated. Of 178 nodules (17, 135, and 26 in classes III, IV, and V, respectively), 71 (40%) were malignant. Prevalence of malignancy was 41%, 29%, and 96% for classes III, IV, and V, respectively. Using sensitivities and specificities for the GEC, NPVs were 91% for the cohort: 88%, 92%, and 26% for classes III, IV, and V, respectively. Molecular testing should be associated with an NPV no lower than that from clinical criteria alone. With the prevalences reported, GEC use may result in more missed cancer diagnoses. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1104-1106, 2016.

Immunohistochemistry

Predictive Value of Tests

Thyroid Neoplasms - surgery

Reproducibility of Results

Humans

Gene Expression Regulation, Neoplastic

Gene Expression Profiling - methods

Academic Medical Centers

Cytodiagnosis - methods

Genetic Testing - methods

Biopsy, Fine-Needle

Thyroid Neoplasms - genetics

Thyroid Nodule - pathology

Retrospective Studies

Thyroid Nodule - surgery

Thyroid Neoplasms - pathology

Details

Title: Subtitle: Correlating thyroid cytology and histopathology: Implications for molecular testing
Creators: Michael J Reed - Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa
Steven M Sperry - Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa
Michael P Gailey - Department of Pathology, University of Iowa, Iowa City, Iowa
Chris S Jensen - Department of Pathology, University of Iowa, Iowa City, Iowa
Robert A Robinson - Department of Pathology, University of Iowa, Iowa City, Iowa
Gerry F Funk - Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa
Nitin A Pagedar - Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Head & neck, Vol.38(7), pp.1104-1106
DOI: 10.1002/hed.24410
PMID: 26900030
NLM abbreviation: Head Neck
ISSN: 1043-3074
eISSN: 1097-0347
Publisher: United States
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 07/2016
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Otolaryngology
Record Identifier: 9984047610502771

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