Journal article
Correlation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impaction
Journal of maxillofacial and oral surgery, Vol.20(1), pp.149-153
2021
DOI: 10.1007/s12663-020-01336-9
PMCID: PMC7855106
PMID: 33584057
Abstract
Aim
This study sought to evaluate the relationship between height of an individual and the presence of impaction of maxillary and mandibular third molars, and to determine the role of genetics in third molar impaction.
Materials and Methods
This was a case–control study, with cases consisted of 200 subjects with third molar impactions; and 200 controls without third molar impactions. Height of subjects was measured, and saliva samples were collected from all the subjects. DNA was extracted from saliva samples. To investigate the role of selected genes in the etiology of third molar impactions, Taqman Genotyping using SNPs identified for jaw growth, height and tooth agenesis was employed. Five candidate genes were investigated using 11 markers (SNPs).
Results
The mean height of cases was significantly lower than that of the control subjects (
p
= 0.04). No difference was found in allele frequency between cases and controls for 10 of the 11 SNPs. However, for rs6504591 the
p
value was near significance (
p
= 0.07) with odd ratio of 2.131. Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars.
Conclusions
Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars. We observed that individuals with third molar impaction tend to have T allele at the locus, suggesting that the T allele at the locus may increase the risk for having an impacted third molar. The rs6504591 G/T variation on human chromosome 17 (WNT9B gene) appears to increase risk by twofolds for impaction albeit with inability to detect significance due to small sample size.
Details
- Title: Subtitle
- Correlation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impaction
- Creators
- Wasiu L. Adeyemo - University of LagosOlutayo James - University of LagosAfisu A. Oladega - Lagos University Teaching HospitalOlawale O. Adamson - Lagos University Teaching HospitalAdeola A. Adekunle - Lagos University Teaching HospitalKehinde D. Olorunsola - Lagos University Teaching HospitalTamara Busch - University of IowaAzeez Butali - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of maxillofacial and oral surgery, Vol.20(1), pp.149-153
- DOI
- 10.1007/s12663-020-01336-9
- PMID
- 33584057
- PMCID
- PMC7855106
- NLM abbreviation
- J Maxillofac Oral Surg
- ISSN
- 0972-8279
- eISSN
- 0974-942X
- Publisher
- Springer India
- Grant note
- K99/R00 / NIH 72429 / Robert Wood Johnson Foundation CRC NO/2014/05 / University of Lagos
- Language
- English
- Date published
- 2021
- Academic Unit
- Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984353930202771
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