Journal article
Correlation between Nasal Membrane Permeability and Nasal Absorption Rate
AAPS PharmSciTech, Vol.14(1), pp.60-63
03/2013
DOI: 10.1208/s12249-012-9884-2
PMCID: PMC3581654
PMID: 23225081
Abstract
The objective of this study was to investigate the relationship between in vitro permeability (P
app) values obtained from isolated nasal tissues and the absorption rates (k
a) of the same compounds following nasal administration in animals and humans. The P
app of a set of 11 drug compounds was measured using animal nasal explants and plasma time–concentration profiles for each of the same compounds following intravenous (IV) and intranasal (IN) administration were experimentally determined or obtained from literature reports. The plasma clearance was estimated from the IV plasma time–concentration profiles, and k
a was determined from the IN plasma time–concentration profiles using a deconvolution approach. The level of correlation between P
app and k
a was established using Pearson correlation analysis. A good correlation (r = 0.77) representing a point-to-point relationship for each of the compounds was observed. This result indicates that the nasal absorption for many drug candidates can be estimated from a readily measured in vitro P
app value.
Details
- Title: Subtitle
- Correlation between Nasal Membrane Permeability and Nasal Absorption Rate
- Creators
- Hefei Zhang - Oncology Clinical Pharmacology Novartis Pharmaceuticals Corporation 180 Park Avenue Florham Park New Jersey 07932 USAChih-Wei Lin - Clinical Pharmacology and Pharmacometrics 100 Abbott Park Road, R4PK AP13A Abbott Park Illinois 60064 USAMaureen Donovan - Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy University of Iowa 115 South Grand Avenue Iowa City Iowa 52242 USA
- Resource Type
- Journal article
- Publication Details
- AAPS PharmSciTech, Vol.14(1), pp.60-63
- Publisher
- Springer US; Boston
- DOI
- 10.1208/s12249-012-9884-2
- PMID
- 23225081
- PMCID
- PMC3581654
- ISSN
- 1530-9932
- eISSN
- 1530-9932
- Language
- English
- Date published
- 03/2013
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065700102771
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