Correlation of Four Single Nucleotide Polymorphisms of the RELN Gene With Schizophrenia

Junjiao Ping; Jie Zhang; Jing Wan; Ashmita Banerjee; Caiying Huang; Jinming Yu; Tingyun Jiang; Baoguo Du

doi:10.12809/eaap2168

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Correlation of Four Single Nucleotide Polymorphisms of the RELN Gene With Schizophrenia

Journal article

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Correlation of Four Single Nucleotide Polymorphisms of the RELN Gene With Schizophrenia

Junjiao Ping, Jie Zhang, Jing Wan, Ashmita Banerjee, Caiying Huang, Jinming Yu, Tingyun Jiang and Baoguo Du

East Asian Archives of Psychiatry, Vol.31(4), pp.112-118

12/29/2021

DOI: 10.12809/eaap2168

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Abstract

OBJECTIVE: This study aims to determine the association between single-nucleotide polymorphisms (SNPs) of the RELN gene and schizophrenia. METHODS: 134 patients aged 16 to 58 (mean, 38.0) years who were diagnosed with acute or chronic schizophrenia at the Zhongshan Third People's Hospital between January 2018 and April 2020 were recruited, as were 64 healthy controls aged 22 to 59 (mean, 45.6) years who matched with the age and sex of the patients. MassARRAY mass spectrometry genotyping technology was used to determine the genotypes of four SNPs of RELN (rs2073559, rs2229864, rs362691, and rs736707). RESULTS: There were no significant between-group or between-sex differences in terms of genotype, allele frequency, or haplotype frequency of the SNPs (all p > 0.05). In the association analysis between genotypes and quantitative traits in the Positive and Negative Syndrome Scale, rs2229864 and rs736707 were associated with the scores for items P3 (hallucinatory behaviour) and G11 (attention disorder), and rs362691 was associated with G10 (disorientation). However, the associations did not remain significant after Bonferroni correction. CONCLUSION: Multiple pathogenic polymorphisms of RELN might be associated with hallucinatory behaviour and attention disorder in Chinese patients with schizophrenia.

Details

Title: Subtitle: Correlation of Four Single Nucleotide Polymorphisms of the RELN Gene With Schizophrenia
Creators: Junjiao Ping - Joint Laboratory of Psychiatric Genetic Research and Department of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Jie Zhang - Joint Laboratory of Psychiatric Genetic Research and Department of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Jing Wan - Department of Early Intervention, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Ashmita Banerjee - University of Iowa
Caiying Huang - Department of Early Intervention, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Jinming Yu - Department of Substance Dependence, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Tingyun Jiang - Department of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Baoguo Du - Department of Clinical Psychology, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, PR China
Resource Type: Journal article
Publication Details: East Asian Archives of Psychiatry, Vol.31(4), pp.112-118
DOI: 10.12809/eaap2168
ISSN: 2078-9947
eISSN: 2224-7041
Language: English
Date published: 12/29/2021
Academic Unit: Psychiatry
Record Identifier: 9984295041202771

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