Journal article
Correlation of Lymph Node Characteristics and Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
OTO open : the official open access journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation, Vol.8(4), e70032
10/2024
DOI: 10.1002/oto2.70032
PMCID: PMC11487070
PMID: 39430065
Abstract
Abstract Objective Identify correlations between lymph node characteristics and extranodal extension (ENE). Study Design Retrospective chart review. Setting Tertiary care center. Methods Patients who underwent neck dissection for oral cavity squamous cell carcinoma from 2004 to 2018 were included, with a starting sample of 496. The primary outcome was ENE in at least 1 lymph node. Additional variables included number of dissected nodes, positive nodes by level, positive lymph node ratio (LNR), and diameter of metastatic deposit and ENE focus. Univariate and multivariate binary logistic regression analyses were performed to determine correlations between included variables and ENE. Results Of the 496 patients, 233 had nodal metastasis (47.0%). 13,814 nodes were removed, with 714 (5.2%) containing metastasis. Of the positive nodes, 28.0% had ENE, 47.2% did not have ENE, and 24.8% were unknown. The mean ENE diameter was 5.1 mm (SD, 9.9). On univariate logistic regression analysis, ipsilateral neck LNR per 0.1 unit increase (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.02‐1.32, P = .02), metastatic deposit size per 1 mm increase (OR 1.06, CI 1.04‐1.08, P < .0001), and clinical T‐ ( P = .02) and N‐class ( P = .0003) significantly correlated with ENE. On multivariate logistic regression analysis, size of metastatic deposit (OR 1.06, CI 1.03‐1.08, P < .0001) remained significantly correlated with ENE. Conclusion Controlling for confounding variables, size of metastatic deposit was an independent predictor of ENE, suggesting that as the metastatic deposit size increases, the odds of extension through the capsule also increases. This may be due to capsule thinning as the deposit grows or could represent the invasive nature of aggressive disease.
Details
- Title: Subtitle
- Correlation of Lymph Node Characteristics and Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
- Creators
- Piper A. Wenzel - University of IowaSteven L. Van Meeteren - University of Iowa Hospitals and ClinicsNitin A. Pagedar - University of Iowa Hospitals and ClinicsMarisa R. Buchakjian - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- OTO open : the official open access journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation, Vol.8(4), e70032
- DOI
- 10.1002/oto2.70032
- PMID
- 39430065
- PMCID
- PMC11487070
- NLM abbreviation
- OTO Open
- ISSN
- 2473-974X
- eISSN
- 2473-974X
- Publisher
- Wiley; HOBOKEN
- Grant note
- National Institutes of Health (NIH) National Cancer Institute: P30CA086862 National Center for Advancing Translational Sciences: UM1TR004403
The authors would like to acknowledge the Holden Comprehensive Cancer Center Oncology Registry. This work was supported by use of resources from the National Institutes of Health (NIH) National Cancer Institute (grant No. P30CA086862) and the National Center for Advancing Translational Sciences (grant No. UM1TR004403).
- Language
- English
- Date published
- 10/2024
- Academic Unit
- The University of Iowa Institute for Vision Research; Otolaryngology
- Record Identifier
- 9984738165202771
Metrics
3 Record Views