Journal article
Correlation of QT interval correction methods during atrial fibrillation and sinus rhythm
The American journal of cardiology, Vol.112(9), pp.1379-1383
11/01/2013
DOI: 10.1016/j.amjcard.2013.06.027
PMID: 23972343
Abstract
The calculation of the corrected QT interval (QTc) is particularly problematic in patients during atrial fibrillation (AF). The aims of this study were to compare the QTc calculated using Bazett's formula in AF and sinus rhythm (SR) and determine whether alternative methods for QT correction were superior to Bazett's, in an effort to define the optimal method for QT correction in patients with AF. We evaluated consecutive patients with persistent AF admitted for initiation of dofetilide. The QT interval was corrected according to the following formulas: Bazett's, Fridericia, and Framingham. We compared the QTc interval on the last electrocardiogram in AF to the first electrocardiogram in SR. The cohort included 54 patients (age 60 ± 10 years, 80% men) with persistent AF for a median of 36 months. Bazett's overestimated QTc during AF compared with SR (464 ± 34 vs 445 ± 38 ms, p = 0.008); in contrast, Framingham underestimated it (385 ± 48 vs 431 ± 40 ms, p <0.001, respectively). However, there was no significant difference between the QTc interval in AF and SR when assessed by Fridericia (435 ± 33 vs 440 ± 35 ms, p = 0.46). There were 24 dofetilide dose reductions based on Bazett's QTc; this would have been avoided in 33% of patients had Fridericia been used. In conclusion, the commonly used Bazett's formula leads to an overestimation of the QTc during AF. This may result in unnecessary reduction in antiarrhythmic doses and thus drug efficacy. These data suggest that the Fridericia most closely approximates the QTc during AF to QTc during SR.
Details
- Title: Subtitle
- Correlation of QT interval correction methods during atrial fibrillation and sinus rhythm
- Creators
- Dan L Musat - Arrhythmia Institute of the Valley Health System, Columbia University College of Physicians & Surgeons, New York, New York and Ridgewood, New Jersey.. Electronic address: musada@valleyhealth.comMehul AdhadukMark W PremingerAysha ArshadTina SichrovskyJonathan S SteinbergSuneet Mittal
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.112(9), pp.1379-1383
- DOI
- 10.1016/j.amjcard.2013.06.027
- PMID
- 23972343
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094311102771
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