Journal article
Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer
Radiology and oncology, Vol.49(3), pp.250-255
09/01/2015
DOI: 10.1515/raon-2015-0032
PMCID: PMC4577221
PMID: 26401130
Abstract
The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADC
) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADC
values differ between tumour subtypes and tissue sampling method.
The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADC
and the Ki-67 index was evaluated.
Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADC
values and the Ki-67 proliferation index (r = −0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.
Because ADC
shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.
Details
- Title: Subtitle
- Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer
- Creators
- Adem Karaman - Atatürk UniversityIrmak Durur-Subasi - Atatürk UniversityFatih Alper - Atatürk UniversityOmer Araz - Atatürk UniversityMahmut Subasi - Erzurum Regional Training and Research HospitalElif Demirci - Atatürk UniversityMevlut Albayrak - Atatürk UniversityGökhan Polat - Atatürk UniversityMetin Akgun - Atatürk UniversityNevzat Karabulut - Pamukkale University
- Resource Type
- Journal article
- Publication Details
- Radiology and oncology, Vol.49(3), pp.250-255
- Publisher
- De Gruyter Open
- DOI
- 10.1515/raon-2015-0032
- PMID
- 26401130
- PMCID
- PMC4577221
- ISSN
- 1318-2099
- eISSN
- 1581-3207
- Number of pages
- 6
- Language
- English
- Date published
- 09/01/2015
- Academic Unit
- Radiology
- Record Identifier
- 9984697639502771
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