Correlation of features on OCT with visual acuity and Gass lesion type in best vitelliform macular dystrophy

Razek G Coussa; Christopher R Fortenbach; D Brice Critser; Malia M Collins; Budd A Tucker; Robert F Mullins; Elliott H Sohn; Edwin M Stone; Ian C Han

doi:10.1136/bmjophth-2021-000860

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Correlation of features on OCT with visual acuity and Gass lesion type in best vitelliform macular dystrophy

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Correlation of features on OCT with visual acuity and Gass lesion type in best vitelliform macular dystrophy

Razek G Coussa, Christopher R Fortenbach, D Brice Critser, Malia M Collins, Budd A Tucker, Robert F Mullins, Elliott H Sohn, Edwin M Stone and Ian C Han

BMJ open ophthalmology, Vol.6(1), p.e000860

12/2021

DOI: 10.1136/bmjophth-2021-000860

PMCID: PMC8655537

PMID: 34993349

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Abstract

ObjectiveTo correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with best vitelliform macular dystrophy (BVMD).Methods and analysisThis is a retrospective case series of consecutive patients with molecularly confirmed BEST1-associated BVMD. OCT scans were reviewed for lesion status and presence of subretinal pillar, focal choroidal excavation (FCE), intraretinal fluid or atrophy. Available OCT angiography images were used to evaluate for the presence of choroidal neovascularisation (CNV). These features were then correlated with BCVA and Gass lesion type.Results95 eyes from 48 patients (mean age 38.9 years, range 4–87) were included. The presence of a pillar (24.2%), FCE (20.0%) and atrophy (7.4%) were associated with poor BCVA (p<0.05). Gass lesion type 1 eyes were correlated with good BCVA (LogMAR <0.4) whereas type 5 eyes had poor BCVA (LogMAR >0.4). Among 65 eyes with longitudinal data (mean follow-up 5.1 years), 7 eyes (10.8%) reverted from higher to lower Gass lesion type; of these, 4 eyes (57.1%) had CNV responsive to intravitreal anti-vascular endothelial growth factor treatment.ConclusionOCT-based structural features are readily identifiable in patients with BVMD and have prognostic importance due to their correlation with BCVA.

Details

Title: Subtitle: Correlation of features on OCT with visual acuity and Gass lesion type in best vitelliform macular dystrophy
Creators: Razek G Coussa
Christopher R Fortenbach
D Brice Critser
Malia M Collins
Budd A Tucker
Robert F Mullins
Elliott H Sohn
Edwin M Stone
Ian C Han
Resource Type: Journal article
Publication Details: BMJ open ophthalmology, Vol.6(1), p.e000860
DOI: 10.1136/bmjophth-2021-000860
PMID: 34993349
PMCID: PMC8655537
NLM abbreviation: BMJ Open Ophthalmol
ISSN: 2397-3269
eISSN: 2397-3269
Grant note: name: Institute for Vision Research, University of Iowa; DOI: 10.13039/100000002, name: National Institutes of Health, award: P30-EY025580, R01-EY024588, R01-EY026547
Language: English
Date published: 12/2021
Academic Unit: The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984201433002771

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