Correlation of histological findings from a large ciliochoroidal melanoma with CT perfusion and 3T MRI dynamic enhancement studies

Jose S Pulido; Norbert G Campeau; Ernst Klotz; Andrew N Primak; Osama Saba; Kaan Gunduz; Herbert Cantrill; Diva Salomao; Cynthia H  McCollough

doi:10.2147/OPTH.S2071

Back

Correlation of histological findings from a large ciliochoroidal melanoma with CT perfusion and 3T MRI dynamic enhancement studies

Journal article

Open access

Peer reviewed

Correlation of histological findings from a large ciliochoroidal melanoma with CT perfusion and 3T MRI dynamic enhancement studies

Jose S Pulido, Norbert G Campeau, Ernst Klotz, Andrew N Primak, Osama Saba, Kaan Gunduz, Herbert Cantrill, Diva Salomao and Cynthia H McCollough

CLINICAL OPHTHALMOLOGY, Vol.2(2), pp.275-281

2008

DOI: 10.2147/OPTH.S2071

PMCID: PMC2693997

PMID: 19668716

Files and links (1)

url

https://doi.org/10.2147/OPTH.S2071View

Published (Version of record) Open Access

Abstract

Background: The initial use of a 64-slice computed tomography (CT) scanner for obtaining quantitative perfusion data from a large ciliochoroidal melanoma, and correlation with 3T magnetic resonance imaging (MRI) dynamic enhancement and tumor histology. Methods: The CT perfusion scan was performed using 80 kVp, 250 mA and 1-sec rotation time for 40 sec. The analysis was performed using commercial perfusion analysis software with a prototype 3-dimensional motion correction tool. Dynamic contrast-enhanced 3-Tesla MRI measured the kinetics of enhancement to estimate the vascular permeability. The time-dependent enhancement patterns were obtained using the average signal intensity using Functool analysis software. The involved globe was enucleated and microscopic evaluation of the tumor was performed. Results: The perfusion parameters blood flow, blood volume and permeability surface area product in the affected eye determined by CT perfusion analysis were 118 ml/100ml/min, 11.3 ml/100 ml and 48 ml/100ml/min. Dynamic MRI enhancement showed maximal intensity increase of 111%. The neoplasm was a ciliochoroidal spindle cell melanoma which was mitotically active (13 mitoses/40 hpf). Vascular loops and arcades were present throughout the tumor. The patient developed metastases within 9 months of presentation. Conclusion: Quantitative CT perfusion analysis of ocular tumors is feasible with motion correction software.

Details

Title: Subtitle: Correlation of histological findings from a large ciliochoroidal melanoma with CT perfusion and 3T MRI dynamic enhancement studies
Creators: Jose S Pulido
Norbert G Campeau
Ernst Klotz
Andrew N Primak
Osama Saba
Kaan Gunduz
Herbert Cantrill
Diva Salomao
Cynthia H McCollough
Resource Type: Journal article
Publication Details: CLINICAL OPHTHALMOLOGY, Vol.2(2), pp.275-281
DOI: 10.2147/OPTH.S2071
PMID: 19668716
PMCID: PMC2693997
NLM abbreviation: Clin Ophthalmol
ISSN: 1177-5483
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984237203902771

Metrics

68 Record Views

4 Times Cited - Web of Science