Journal article
Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma
Skeletal radiology, Vol.41(11), pp.1453-1461
11/01/2012
DOI: 10.1007/s00256-012-1383-8
PMID: 22406919
Abstract
The aim of this work was to determine the role of MRI in interpreting abnormal signals within bones and soft tissues adjacent to tumor bulk of osteosarcoma and Ewing's sarcoma in a pediatric population by correlating MR findings with histopathology.
Thirty patients met the inclusion criteria, which included (1) osteosarcoma or Ewing's sarcoma, (2) MR studies no more than 2 months prior to surgery, (3) presence of abnormal MR signal surrounding the tumor bulk, (4) pathological material from resected tumor. The patients received standard neoadjuvant chemotherapy. Using grid maps on gross pathology specimens, the abnormal MR areas around the tumor were matched with the corresponding grid sections. Histopathology slides of these sections were then analyzed to determine the nature of the regions of interest. The MR/pathological correlation was evaluated using Mann-Whitney U test and Fisher's exact test.
Twenty-seven patients had osteosarcoma and three patients had Ewing's sarcoma. Of the studied areas, 17.4% were positive for tumor (viable or necrotic). There was no statistically significant correlation between areas positive for tumor and age, gender, signal extent and intensity on MRI, or tissue type. There was, however, a statistically significant correlation between presence of tumor and the appearance of abnormal soft tissue signals. A feathery appearance correlated with tumor-negative areas whereas a bulky appearance correlated with tumor-positive regions.
MR imaging is helpful in identifying the nature of abnormal signal areas surrounding bone sarcomas that are more likely to be tumor-free, particularly when the signal in the soft tissues surrounding the tumor is feathery and edema-like in appearance.
Details
- Title: Subtitle
- Correlation of non-mass-like abnormal MR signal intensity with pathological findings surrounding pediatric osteosarcoma and Ewing's sarcoma
- Creators
- Karim Z. Masrouha - American University of Beirut Medical CenterKhaled M. Musallam - American University of BeirutAlexis Bou Samra - American University of Beirut Medical CenterAyman Tawil - American University of Beirut Medical CenterRachid Haidar - American University of Beirut Medical CenterZaher Chakhachiro - American University of Beirut Medical CenterSaid Saghieh - American University of Beirut Medical CenterAbeer Abdallah - American University of Beirut Medical CenterRaya Saab - American University of BeirutSamar Muwakkit - American University of BeirutMiguel R. Abboud - American University of BeirutNabil J. Khoury - American University of Beirut Medical Center
- Resource Type
- Journal article
- Publication Details
- Skeletal radiology, Vol.41(11), pp.1453-1461
- Publisher
- Springer Nature
- DOI
- 10.1007/s00256-012-1383-8
- PMID
- 22406919
- ISSN
- 0364-2348
- eISSN
- 1432-2161
- Number of pages
- 9
- Language
- English
- Date published
- 11/01/2012
- Academic Unit
- Radiology
- Record Identifier
- 9984697723402771
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