Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss

W D Lagrèze; R H Kardon

doi:10.1007/s004170050096

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Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss

Journal article

Peer reviewed

Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss

W D Lagrèze and R H Kardon

Graefe's archive for clinical and experimental ophthalmology, Vol.236(6), pp.401-404

06/1998

DOI: 10.1007/s004170050096

PMID: 9646082

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Abstract

The relative afferent papillary defect (RAPD) is an important parameter for quantifying the loss of neuronal function in asymmetric optic nerve disease. We wanted to assess its correlation with retinal ganglion cell loss, estimated from visual field defects, using a recently described method. In 36 patients with unilateral optic nerve disease, the RAPD was measured using an automated, computerized infrared pupillometer. The percentage of ganglion cell loss was estimated with clear templates. We found a highly significant correlation between the RAPD and estimated ganglion cell loss. The correlation was higher for Humphrey visual fields than for Goldmann visual fields measured with the 14e and 12e stimulus. The RAPD correlates well with estimated retinal ganglion cell loss in optic nerve disease. Humphrey visual fields seem to reflect the ganglion cell loss better than Goldmann visual fields. The spatial distribution of pupillomotor retinal ganglion cells seems to be proportional to the distribution of light-sensitive ganglion cells projecting to the lateral geniculate nucleus.

Optic Nerve Diseases - pathology

Optic Nerve Diseases - complications

Pupil Disorders - etiology

Image Processing, Computer-Assisted

Optic Nerve Diseases - physiopathology

Visual Fields

Cell Count

Humans

Pupil Disorders - physiopathology

Visual Field Tests

Retinal Ganglion Cells - pathology

Details

Title: Subtitle: Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss
Creators: W D Lagrèze - Universitäts-Augenklinik, Freiburg, Germany. lagreze@aug.ukl.uni-freiburg.de
R H Kardon
Resource Type: Journal article
Publication Details: Graefe's archive for clinical and experimental ophthalmology, Vol.236(6), pp.401-404
DOI: 10.1007/s004170050096
PMID: 9646082
NLM abbreviation: Graefes Arch Clin Exp Ophthalmol
ISSN: 0721-832X
eISSN: 1435-702X
Publisher: Germany
Language: English
Date published: 06/1998
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979920002771

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